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- W2134804290 abstract "Mucosal and systemic (serum) immune responses were studied after oral, anal or intramuscular (i.m.) immunization with particulate (Vibrio anguillarum) or soluble (ferritin) antigen. Antigen specific antibodies were found by ELISA in skin mucus after repeated oral or anal administration of bacteria, but not after immunization with ferritin. Daily feeding with bacteria did not give detectable antibodies in serum, while regular oral administration of ferritin resulted in an increase of specific antibodies during the first 3 weeks. From that time immunosuppression was observed, as the antibody titre decreased despite the continued ferritin feeding. Immunosuppression was also found after a second anal intubation or i.m. injection with ferritin, independent of the route of priming (i.m. or anal). On the contrary, a second anal intubation of bacteria resulted in a secondary serum response. These results combined with those reported in Parts I and II of the study indicate an important immunological role for the second gut segment. Because mucosal as well as serum responses can be obtained by anal immunization with bacteria, the significance for oral vaccination is discussed." @default.
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- W2134804290 date "1989-08-01" @default.
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- W2134804290 title "Immunological importance of the second gut segment of carp. III. Systemic and/or mucosal immune responses after immunization with soluble or particulate antigen" @default.
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- W2134804290 doi "https://doi.org/10.1111/j.1095-8649.1989.tb02967.x" @default.
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