FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134808941> ?p ?o ?g. }

• W2134808941 endingPage "936" @default.
• W2134808941 startingPage "928" @default.
• W2134808941 abstract "In this study, food-deprived (18 h) control rats and rats with alloxan-induced diabetes were orally administered saline or the amino acid leucine to assess whether it regulates protein synthesis independently of a change in serum insulin concentrations. Immediately after leucine administration, diabetic rats were infused with insulin (0.0, 4.0, or 20 pmol · min−1 · kg−1) for 1 h to examine the role of the hormone in the protein synthetic response to leucine. In control rats, leucine stimulated protein synthesis by 58% and increased phosphorylation of the translational repressor, eukaryotic initiation factor (eIF) 4E-binding protein (BP)-1, 4E-BP1, fivefold. Consequently, association of the mRNA cap-binding protein eukaryotic initiation factor (eIF)4E with 4E-BP1 was reduced to 50% of control values, and eIF4G•eIF4E complex assembly was increased 80%. Furthermore, leucine increased the phosphorylation of the 70-kDa ribosomal protein S6 (rp S6) and the ribosomal protein S6 kinase (S6K1). Diabetes attenuated protein synthesis compared with control rats. Nonetheless, in diabetic rats, leucine increased protein synthesis by 53% without concomitant changes in the phosphorylation of 4E-BP1 or S6K1. Skeletal muscle protein synthesis was stimulated in diabetic rats infused with insulin, but rates of synthesis remained less than values in nondiabetic controls that were administered leucine. Phosphorylation of 4E-BP1 and S6K1 was increased in diabetic rats infused with insulin in a dose-dependent manner, and the response was enhanced by leucine. The results suggest that leucine enhances protein synthesis in skeletal muscle through both insulin-dependent and -independent mechanisms. The insulin-dependent mechanism is associated with increased phosphorylation of 4E-BP1 and S6K1. In contrast, the insulin-independent effect on protein synthesis is mediated by an unknown mechanism." @default.
• W2134808941 created "2016-06-24" @default.
• W2134808941 creator A5005861452 @default.
• W2134808941 creator A5023696703 @default.
• W2134808941 creator A5033878744 @default.
• W2134808941 creator A5034546492 @default.
• W2134808941 creator A5042398862 @default.
• W2134808941 creator A5054423139 @default.
• W2134808941 creator A5073807348 @default.
• W2134808941 creator A5077337988 @default.
• W2134808941 date "2002-04-01" @default.
• W2134808941 modified "2023-10-15" @default.
• W2134808941 title "Orally Administered Leucine Enhances Protein Synthesis in Skeletal Muscle of Diabetic Rats in the Absence of Increases in 4E-BP1 or S6K1 Phosphorylation" @default.
• W2134808941 cites W113427876 @default.
• W2134808941 cites W1491561248 @default.
• W2134808941 cites W1512892617 @default.
• W2134808941 cites W1577717356 @default.
• W2134808941 cites W1587901430 @default.
• W2134808941 cites W1726025741 @default.
• W2134808941 cites W1868948982 @default.
• W2134808941 cites W1892680963 @default.
• W2134808941 cites W1896066594 @default.
• W2134808941 cites W1943406382 @default.
• W2134808941 cites W1966059275 @default.
• W2134808941 cites W1969442037 @default.
• W2134808941 cites W1995201350 @default.
• W2134808941 cites W2001901848 @default.
• W2134808941 cites W2002111026 @default.
• W2134808941 cites W2007694780 @default.
• W2134808941 cites W2020721543 @default.
• W2134808941 cites W2035016947 @default.
• W2134808941 cites W2048293676 @default.
• W2134808941 cites W2050788206 @default.
• W2134808941 cites W2053495088 @default.
• W2134808941 cites W2057365575 @default.
• W2134808941 cites W2079537922 @default.
• W2134808941 cites W2089115195 @default.
• W2134808941 cites W2089582113 @default.
• W2134808941 cites W2101921236 @default.
• W2134808941 cites W2123231624 @default.
• W2134808941 cites W2131355261 @default.
• W2134808941 cites W2142716752 @default.
• W2134808941 cites W2147067379 @default.
• W2134808941 cites W2151192251 @default.
• W2134808941 cites W2165591131 @default.
• W2134808941 cites W2180321225 @default.
• W2134808941 cites W2193453723 @default.
• W2134808941 cites W2207041716 @default.
• W2134808941 cites W2233627447 @default.
• W2134808941 cites W2239103220 @default.
• W2134808941 cites W2345199091 @default.
• W2134808941 cites W4239278482 @default.
• W2134808941 cites W4251148712 @default.
• W2134808941 doi "https://doi.org/10.2337/diabetes.51.4.928" @default.
• W2134808941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11916909" @default.
• W2134808941 hasPublicationYear "2002" @default.
• W2134808941 type Work @default.
• W2134808941 sameAs 2134808941 @default.
• W2134808941 citedByCount "163" @default.
• W2134808941 countsByYear W21348089412012 @default.
• W2134808941 countsByYear W21348089412013 @default.
• W2134808941 countsByYear W21348089412014 @default.
• W2134808941 countsByYear W21348089412015 @default.
• W2134808941 countsByYear W21348089412016 @default.
• W2134808941 countsByYear W21348089412017 @default.
• W2134808941 countsByYear W21348089412018 @default.
• W2134808941 countsByYear W21348089412019 @default.
• W2134808941 countsByYear W21348089412020 @default.
• W2134808941 countsByYear W21348089412021 @default.
• W2134808941 countsByYear W21348089412022 @default.
• W2134808941 countsByYear W21348089412023 @default.
• W2134808941 crossrefType "journal-article" @default.
• W2134808941 hasAuthorship W2134808941A5005861452 @default.
• W2134808941 hasAuthorship W2134808941A5023696703 @default.
• W2134808941 hasAuthorship W2134808941A5033878744 @default.
• W2134808941 hasAuthorship W2134808941A5034546492 @default.
• W2134808941 hasAuthorship W2134808941A5042398862 @default.
• W2134808941 hasAuthorship W2134808941A5054423139 @default.
• W2134808941 hasAuthorship W2134808941A5073807348 @default.
• W2134808941 hasAuthorship W2134808941A5077337988 @default.
• W2134808941 hasBestOaLocation W21348089411 @default.
• W2134808941 hasConcept C104202773 @default.
• W2134808941 hasConcept C104317684 @default.
• W2134808941 hasConcept C105580179 @default.
• W2134808941 hasConcept C11960822 @default.
• W2134808941 hasConcept C126322002 @default.
• W2134808941 hasConcept C134018914 @default.
• W2134808941 hasConcept C149364088 @default.
• W2134808941 hasConcept C2776580952 @default.
• W2134808941 hasConcept C2779306644 @default.
• W2134808941 hasConcept C2779959927 @default.
• W2134808941 hasConcept C2780926556 @default.
• W2134808941 hasConcept C3675279 @default.
• W2134808941 hasConcept C515207424 @default.
• W2134808941 hasConcept C55493867 @default.
• W2134808941 hasConcept C71924100 @default.
• W2134808941 hasConcept C75217442 @default.
• W2134808941 hasConcept C86803240 @default.

• next