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• W2134811220 endingPage "2777" @default.
• W2134811220 startingPage "2777" @default.
• W2134811220 abstract "The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary disease is uncertain. Study of CETP genotypes can help better understand the relevance of this pathway to lipid metabolism and disease risk.To assess associations of CETP genotypes with CETP phenotypes, lipid levels, and coronary risk.Studies published between January 1970 and January 2008 were identified through computer-based and manual searches using MEDLINE, EMBASE, BIOSIS, Science Citation Index, and the Chinese National Knowledge Infrastructure Database. Previously unreported studies were sought through correspondence with investigators.Relevant studies related principally to 3 common (TaqIB [rs708272], I405V [rs5882], and -629C>A [rs1800775]) and 3 uncommon (D442G [rs2303790], -631C>A [rs1800776], and R451Q [rs1800777]) CETP polymorphisms.Information on CETP genotypes, CETP phenotypes, lipid levels, coronary disease, and study characteristics was abstracted from publications, supplied by investigators, or both.Ninety-two studies had data on CETP phenotypes, lipid levels, or both in 113,833 healthy participants, and 46 studies had data on 27,196 coronary cases and 55,338 controls. For each A allele inherited, individuals with the TaqIB polymorphism had lower mean CETP mass (-9.7%; 95% confidence interval [CI], -11.7% to -7.8%), lower mean CETP activity (-8.6%; 95% CI, -13.0% to -4.1%), higher mean high-density lipoprotein cholesterol (HDL-C) concentrations (4.5%; 95% CI, 3.8%-5.2%), and higher mean apolipoprotein A-I concentrations (2.4%; 95% CI, 1.6%-3.2%). The pattern of findings was very similar with the I405V and -629C>A polymorphisms. The combined per-allele odds ratios (ORs) for coronary disease were 0.95 (95% CI, 0.92-0.99) for TaqIB, 0.94 (95% CI, 0.89-1.00) for I405V, and 0.95 (95% CI, 0.91-1.00) for -629C>A.Three CETP genotypes that are associated with moderate inhibition of CETP activity (and, therefore, modestly higher HDL-C levels) show weakly inverse associations with coronary risk. The ORs for coronary disease were compatible with the expected reductions in risk for equivalent increases in HDL-C concentration in available prospective studies." @default.
• W2134811220 created "2016-06-24" @default.
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• W2134811220 date "2008-06-18" @default.
• W2134811220 modified "2023-10-01" @default.
• W2134811220 title "Association of Cholesteryl Ester Transfer Protein Genotypes With CETP Mass and Activity, Lipid Levels, and Coronary Risk" @default.
• W2134811220 cites W1491993380 @default.
• W2134811220 cites W1497581750 @default.
• W2134811220 cites W1575441863 @default.
• W2134811220 cites W1607804102 @default.
• W2134811220 cites W1684782219 @default.
• W2134811220 cites W1757354807 @default.
• W2134811220 cites W185370342 @default.
• W2134811220 cites W1883778420 @default.
• W2134811220 cites W1916713309 @default.
• W2134811220 cites W1918451759 @default.
• W2134811220 cites W1926790482 @default.
• W2134811220 cites W1956687999 @default.
• W2134811220 cites W1959861043 @default.
• W2134811220 cites W1966387527 @default.
• W2134811220 cites W1967419648 @default.
• W2134811220 cites W1968204283 @default.
• W2134811220 cites W1970652477 @default.
• W2134811220 cites W1971226909 @default.
• W2134811220 cites W1974879356 @default.
• W2134811220 cites W1976181942 @default.
• W2134811220 cites W1976923914 @default.
• W2134811220 cites W1981044091 @default.
• W2134811220 cites W1981675684 @default.
• W2134811220 cites W1983793079 @default.
• W2134811220 cites W1984255150 @default.
• W2134811220 cites W1984531311 @default.
• W2134811220 cites W1990166738 @default.
• W2134811220 cites W1990530378 @default.
• W2134811220 cites W1991804203 @default.
• W2134811220 cites W1992141559 @default.
• W2134811220 cites W1992802120 @default.
• W2134811220 cites W1994790699 @default.
• W2134811220 cites W1995316389 @default.
• W2134811220 cites W1998737330 @default.
• W2134811220 cites W2001158939 @default.
• W2134811220 cites W2001790643 @default.
• W2134811220 cites W2002081006 @default.
• W2134811220 cites W2002173050 @default.
• W2134811220 cites W2003671495 @default.
• W2134811220 cites W2005247682 @default.
• W2134811220 cites W2010480529 @default.
• W2134811220 cites W2013731962 @default.
• W2134811220 cites W2017480132 @default.
• W2134811220 cites W2019358153 @default.
• W2134811220 cites W2023582909 @default.
• W2134811220 cites W2026234937 @default.
• W2134811220 cites W2026389035 @default.
• W2134811220 cites W2026869877 @default.
• W2134811220 cites W2028662039 @default.
• W2134811220 cites W2031498851 @default.
• W2134811220 cites W2034259989 @default.
• W2134811220 cites W2036194401 @default.
• W2134811220 cites W2039429939 @default.
• W2134811220 cites W2041054617 @default.
• W2134811220 cites W2042341024 @default.
• W2134811220 cites W2042833670 @default.
• W2134811220 cites W2043684315 @default.
• W2134811220 cites W2048442514 @default.
• W2134811220 cites W2048760408 @default.
• W2134811220 cites W2049833722 @default.
• W2134811220 cites W2050047378 @default.
• W2134811220 cites W2050969923 @default.
• W2134811220 cites W2054631376 @default.
• W2134811220 cites W2055319579 @default.
• W2134811220 cites W2058029138 @default.
• W2134811220 cites W2058147778 @default.
• W2134811220 cites W2059088778 @default.
• W2134811220 cites W2061186478 @default.
• W2134811220 cites W2062244663 @default.
• W2134811220 cites W2068209188 @default.
• W2134811220 cites W2071102243 @default.
• W2134811220 cites W2073542195 @default.
• W2134811220 cites W2073638666 @default.
• W2134811220 cites W2073841042 @default.
• W2134811220 cites W2075198625 @default.
• W2134811220 cites W2077420019 @default.
• W2134811220 cites W2077967771 @default.
• W2134811220 cites W2078882205 @default.
• W2134811220 cites W2079068385 @default.
• W2134811220 cites W2081632741 @default.
• W2134811220 cites W2084180257 @default.
• W2134811220 cites W2087403702 @default.
• W2134811220 cites W2089610798 @default.
• W2134811220 cites W2090568412 @default.

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