Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134846845> ?p ?o ?g. }
- W2134846845 endingPage "177" @default.
- W2134846845 startingPage "168" @default.
- W2134846845 abstract "Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent stem cells (iPSCs) remains largely unexplored. Here we report, using an untargeted metabolomics approach, that human iPSCs share a pluripotent metabolomic signature with embryonic stem cells (ESCs) that is distinct from their parental cells, and that is characterized by changes in metabolites involved in cellular respiration. Examination of cellular bioenergetics corroborated with our metabolomic analysis, and demonstrated that somatic cells convert from an oxidative state to a glycolytic state in pluripotency. Interestingly, the bioenergetics of various somatic cells correlated with their reprogramming efficiencies. We further identified metabolites that differ between iPSCs and ESCs, which revealed novel metabolic pathways that play a critical role in regulating somatic cell reprogramming. Our findings are the first to globally analyze the metabolome of iPSCs, and provide mechanistic insight into a new layer of regulation involved in inducing pluripotency, and in evaluating iPSC and ESC equivalence." @default.
- W2134846845 created "2016-06-24" @default.
- W2134846845 creator A5003032786 @default.
- W2134846845 creator A5010237445 @default.
- W2134846845 creator A5016038041 @default.
- W2134846845 creator A5028556067 @default.
- W2134846845 creator A5033757285 @default.
- W2134846845 creator A5034335324 @default.
- W2134846845 creator A5046087604 @default.
- W2134846845 creator A5047262932 @default.
- W2134846845 creator A5050690657 @default.
- W2134846845 creator A5051198855 @default.
- W2134846845 creator A5051333971 @default.
- W2134846845 creator A5057313077 @default.
- W2134846845 creator A5067311581 @default.
- W2134846845 creator A5086398688 @default.
- W2134846845 creator A5087519016 @default.
- W2134846845 date "2011-11-08" @default.
- W2134846845 modified "2023-10-18" @default.
- W2134846845 title "The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming" @default.
- W2134846845 cites W1964010911 @default.
- W2134846845 cites W1978880986 @default.
- W2134846845 cites W1981809048 @default.
- W2134846845 cites W1986500594 @default.
- W2134846845 cites W1986832923 @default.
- W2134846845 cites W1987774343 @default.
- W2134846845 cites W1999044086 @default.
- W2134846845 cites W2001284661 @default.
- W2134846845 cites W2006557127 @default.
- W2134846845 cites W2019019085 @default.
- W2134846845 cites W2025738240 @default.
- W2134846845 cites W2032045112 @default.
- W2134846845 cites W2059223857 @default.
- W2134846845 cites W2059378220 @default.
- W2134846845 cites W2073610802 @default.
- W2134846845 cites W2082414890 @default.
- W2134846845 cites W2086943348 @default.
- W2134846845 cites W2094049581 @default.
- W2134846845 cites W2097259163 @default.
- W2134846845 cites W2099616702 @default.
- W2134846845 cites W2102560467 @default.
- W2134846845 cites W2112156060 @default.
- W2134846845 cites W2125987139 @default.
- W2134846845 cites W2126580353 @default.
- W2134846845 cites W2135086442 @default.
- W2134846845 cites W2136532823 @default.
- W2134846845 cites W2138977668 @default.
- W2134846845 cites W2142046859 @default.
- W2134846845 cites W2155680682 @default.
- W2134846845 cites W2161315819 @default.
- W2134846845 cites W2164045953 @default.
- W2134846845 cites W2170331810 @default.
- W2134846845 cites W2183857205 @default.
- W2134846845 doi "https://doi.org/10.1038/cr.2011.177" @default.
- W2134846845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3252494" @default.
- W2134846845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22064701" @default.
- W2134846845 hasPublicationYear "2011" @default.
- W2134846845 type Work @default.
- W2134846845 sameAs 2134846845 @default.
- W2134846845 citedByCount "433" @default.
- W2134846845 countsByYear W21348468452012 @default.
- W2134846845 countsByYear W21348468452013 @default.
- W2134846845 countsByYear W21348468452014 @default.
- W2134846845 countsByYear W21348468452015 @default.
- W2134846845 countsByYear W21348468452016 @default.
- W2134846845 countsByYear W21348468452017 @default.
- W2134846845 countsByYear W21348468452018 @default.
- W2134846845 countsByYear W21348468452019 @default.
- W2134846845 countsByYear W21348468452020 @default.
- W2134846845 countsByYear W21348468452021 @default.
- W2134846845 countsByYear W21348468452022 @default.
- W2134846845 countsByYear W21348468452023 @default.
- W2134846845 crossrefType "journal-article" @default.
- W2134846845 hasAuthorship W2134846845A5003032786 @default.
- W2134846845 hasAuthorship W2134846845A5010237445 @default.
- W2134846845 hasAuthorship W2134846845A5016038041 @default.
- W2134846845 hasAuthorship W2134846845A5028556067 @default.
- W2134846845 hasAuthorship W2134846845A5033757285 @default.
- W2134846845 hasAuthorship W2134846845A5034335324 @default.
- W2134846845 hasAuthorship W2134846845A5046087604 @default.
- W2134846845 hasAuthorship W2134846845A5047262932 @default.
- W2134846845 hasAuthorship W2134846845A5050690657 @default.
- W2134846845 hasAuthorship W2134846845A5051198855 @default.
- W2134846845 hasAuthorship W2134846845A5051333971 @default.
- W2134846845 hasAuthorship W2134846845A5057313077 @default.
- W2134846845 hasAuthorship W2134846845A5067311581 @default.
- W2134846845 hasAuthorship W2134846845A5086398688 @default.
- W2134846845 hasAuthorship W2134846845A5087519016 @default.
- W2134846845 hasBestOaLocation W21348468451 @default.
- W2134846845 hasConcept C104317684 @default.
- W2134846845 hasConcept C107459253 @default.
- W2134846845 hasConcept C134305767 @default.
- W2134846845 hasConcept C135870905 @default.
- W2134846845 hasConcept C143948831 @default.
- W2134846845 hasConcept C145103041 @default.
- W2134846845 hasConcept C148738053 @default.
- W2134846845 hasConcept C1491633281 @default.
- W2134846845 hasConcept C21565614 @default.