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- W2134850606 abstract "The current treatment of choice for metastatic pancreatic cancer involves single-agent gemcitabine or a combination of gemcitabine with capecitabine or erlotinib (a tyrosine kinase inhibitor). Only 25–30% of patients respond to this treatment and patients who do respond initially ultimately exhibit disease progression. Median survival for pancreatic cancer patients has reached a plateau due to inherent and acquired resistance to these agents. Key molecular factors implicated in this resistance include: deficiencies in drug uptake, alteration of drug targets, activation of DNA repair pathways, resistance to apoptosis and the contribution of the tumor microenvironment. Moreover, for newer agents including tyrosine kinase inhibitors, overexpression of signaling proteins, mutations in kinase domains, activation of alternative pathways, mutations of genes downstream of the target and/or amplification of the target represent key challenges for treatment efficacy. Here we will review the contribution of known mechanisms and markers of resistance to key pancreatic cancer drug treatments." @default.
- W2134850606 created "2016-06-24" @default.
- W2134850606 creator A5006249276 @default.
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- W2134850606 creator A5076159971 @default.
- W2134850606 creator A5077091444 @default.
- W2134850606 creator A5080035538 @default.
- W2134850606 date "2010-10-01" @default.
- W2134850606 modified "2023-10-02" @default.
- W2134850606 title "Challenges of drug resistance in the management of pancreatic cancer" @default.
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