FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134862643> ?p ?o ?g. }

• W2134862643 abstract "Isatin (1H-indole-2,3 dione) is an endogenous compound that may act as a physiological regulator of muscle contraction by reducing cGMP production by inhibition of guanylyl cyclase (GC) activity. Intracellular cGMP levels can regulate the contractile response of smooth muscle. Therefore, in the present study we investigated the effects of seven novel carbamate derivatives of isatin, namely C1-C7, on the contractility of aortic rings from Wistar rats. Carbamates C1 and C6 most effectively promoted endothelium-dependent relaxation of aortic rings pretreated with 10 micromol/L phenylephrine (PE) to induce contraction. The concentration of the C1 and C6 carbamates necessary to reduce PE-induced aortic contraction by 50% (IC(50)) was 5.6 +/- 1.0 and 48.4 +/- 3.4 micromol/L, respectively. Carbamate derivative-induced vasodilation required an intact endothelium, which is responsible for nitric oxide (NO) release. Pretreatment of rings with 100 micromol/L naloxone or 10 micromol/L atropine prevented the C1- and C6-mediated vascular relaxation, indicating that the vasodilatory activity was dependent on the activation of opioid or muscarinic receptors, respectively. The results of our studies provide insights into the role of novel carbamates in the regulation of vascular tone. Carbamates could stimulate NO synthesis, which induces vasodilation primarily by stimulation of GC and cGMP production. Taken together, our findings suggest that carbamate derivative-induced vasodilation may be considered an alternative treatment for primary and/or secondary hypertension." @default.
• W2134862643 created "2016-06-24" @default.
• W2134862643 creator A5005399436 @default.
• W2134862643 creator A5020297051 @default.
• W2134862643 creator A5058580208 @default.
• W2134862643 creator A5065311066 @default.
• W2134862643 creator A5067786337 @default.
• W2134862643 creator A5079304435 @default.
• W2134862643 creator A5090252220 @default.
• W2134862643 date "2008-09-01" @default.
• W2134862643 modified "2023-10-18" @default.
• W2134862643 title "VASODILATORY ACTIVITY OF NOVEL CARBAMATE DERIVATIVES OF ISATIN" @default.
• W2134862643 cites W1964498876 @default.
• W2134862643 cites W1977409721 @default.
• W2134862643 cites W1983989743 @default.
• W2134862643 cites W1985320052 @default.
• W2134862643 cites W1988171949 @default.
• W2134862643 cites W1988979797 @default.
• W2134862643 cites W1993680861 @default.
• W2134862643 cites W2003125972 @default.
• W2134862643 cites W2025817658 @default.
• W2134862643 cites W2032906429 @default.
• W2134862643 cites W2037225314 @default.
• W2134862643 cites W2038265124 @default.
• W2134862643 cites W2044030798 @default.
• W2134862643 cites W2047226060 @default.
• W2134862643 cites W2047274537 @default.
• W2134862643 cites W2048126508 @default.
• W2134862643 cites W2052614794 @default.
• W2134862643 cites W2062541458 @default.
• W2134862643 cites W2066546247 @default.
• W2134862643 cites W2079660588 @default.
• W2134862643 cites W2084064829 @default.
• W2134862643 cites W2089236884 @default.
• W2134862643 cites W2090904392 @default.
• W2134862643 cites W2093217834 @default.
• W2134862643 cites W2103215838 @default.
• W2134862643 cites W2128788119 @default.
• W2134862643 cites W2169429079 @default.
• W2134862643 cites W2950558506 @default.
• W2134862643 cites W4229755335 @default.
• W2134862643 doi "https://doi.org/10.1111/j.1440-1681.2008.04959.x" @default.
• W2134862643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18505449" @default.
• W2134862643 hasPublicationYear "2008" @default.
• W2134862643 type Work @default.
• W2134862643 sameAs 2134862643 @default.
• W2134862643 citedByCount "4" @default.
• W2134862643 countsByYear W21348626432017 @default.
• W2134862643 crossrefType "journal-article" @default.
• W2134862643 hasAuthorship W2134862643A5005399436 @default.
• W2134862643 hasAuthorship W2134862643A5020297051 @default.
• W2134862643 hasAuthorship W2134862643A5058580208 @default.
• W2134862643 hasAuthorship W2134862643A5065311066 @default.
• W2134862643 hasAuthorship W2134862643A5067786337 @default.
• W2134862643 hasAuthorship W2134862643A5079304435 @default.
• W2134862643 hasAuthorship W2134862643A5090252220 @default.
• W2134862643 hasConcept C120770815 @default.
• W2134862643 hasConcept C126322002 @default.
• W2134862643 hasConcept C163415756 @default.
• W2134862643 hasConcept C178790620 @default.
• W2134862643 hasConcept C185592680 @default.
• W2134862643 hasConcept C2775910092 @default.
• W2134862643 hasConcept C2777952589 @default.
• W2134862643 hasConcept C2779395532 @default.
• W2134862643 hasConcept C2992686903 @default.
• W2134862643 hasConcept C519581460 @default.
• W2134862643 hasConcept C55493867 @default.
• W2134862643 hasConcept C71924100 @default.
• W2134862643 hasConcept C84393581 @default.
• W2134862643 hasConcept C98274493 @default.
• W2134862643 hasConceptScore W2134862643C120770815 @default.
• W2134862643 hasConceptScore W2134862643C126322002 @default.
• W2134862643 hasConceptScore W2134862643C163415756 @default.
• W2134862643 hasConceptScore W2134862643C178790620 @default.
• W2134862643 hasConceptScore W2134862643C185592680 @default.
• W2134862643 hasConceptScore W2134862643C2775910092 @default.
• W2134862643 hasConceptScore W2134862643C2777952589 @default.
• W2134862643 hasConceptScore W2134862643C2779395532 @default.
• W2134862643 hasConceptScore W2134862643C2992686903 @default.
• W2134862643 hasConceptScore W2134862643C519581460 @default.
• W2134862643 hasConceptScore W2134862643C55493867 @default.
• W2134862643 hasConceptScore W2134862643C71924100 @default.
• W2134862643 hasConceptScore W2134862643C84393581 @default.
• W2134862643 hasConceptScore W2134862643C98274493 @default.
• W2134862643 hasLocation W21348626431 @default.
• W2134862643 hasLocation W21348626432 @default.
• W2134862643 hasOpenAccess W2134862643 @default.
• W2134862643 hasPrimaryLocation W21348626431 @default.
• W2134862643 hasRelatedWork W1968985689 @default.
• W2134862643 hasRelatedWork W1976276027 @default.
• W2134862643 hasRelatedWork W1983556643 @default.
• W2134862643 hasRelatedWork W2033714002 @default.
• W2134862643 hasRelatedWork W2036748014 @default.
• W2134862643 hasRelatedWork W2049860005 @default.
• W2134862643 hasRelatedWork W2077273330 @default.
• W2134862643 hasRelatedWork W2080090333 @default.
• W2134862643 hasRelatedWork W2083203405 @default.
• W2134862643 hasRelatedWork W2130072620 @default.
• W2134862643 hasRelatedWork W2156534692 @default.
• W2134862643 hasRelatedWork W2163124809 @default.

• next