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• W2134920200 endingPage "347" @default.
• W2134920200 startingPage "341" @default.
• W2134920200 abstract "In selective REM sleep deprivation (SRSD), the occurrence of stage REM is repeatedly interrupted by short awakenings. Typically, the interventions aggregate in clusters resembling the REM episodes in undisturbed sleep. This salient phenomenon can easily be explained if the nonREM-REM sleep process is continued during the periods of forced wakefulness. However, earlier studies have alternatively suggested that awakenings from sleep might rather discontinue and reset the ultradian process. Theoretically, the two explanations predict a different distribution of REM episode duration. We evaluated 117 SRSD treatment nights recorded from 14 depressive inpatients receiving low dosages of Trimipramine. The alarms were triggered by an automatic mechanism for the detection of REM sleep and had to be canceled by the subjects themselves. The REM episodes were determined as in undisturbed sleep-they had to include the remaining REM activity and were separated by 30 min without REM epochs. The frequency histogram of REM episodes declined exponentially with episode duration for each of the first four sleep cycles. The duration of nonREM intervals revealed bimodal distributions. These results were found consistent with the model assuming a reset of the ultradian cycle upon awakening. Whether REM or nonREM activity is resumed on return to sleep can be modeled by a random decision whereby the probability for REM sleep might depend on the momentary REM pressure." @default.
• W2134920200 created "2016-06-24" @default.
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• W2134920200 date "2002-11-01" @default.
• W2134920200 modified "2023-10-01" @default.
• W2134920200 title "Is the nonREM–REM sleep cycle reset by forced awakenings from REM sleep?" @default.
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• W2134920200 doi "https://doi.org/10.1016/s0031-9384(02)00862-4" @default.
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