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• W2134927256 endingPage "667" @default.
• W2134927256 startingPage "662" @default.
• W2134927256 abstract "Systemic lupus erythematosus (SLE) in a multisystem autoimmune disorder characterized by multiorgan pathology and autoantibodies against a variety of autoantigens. The CD28 and CTLA-4 genes might be candidate genes for SLE, because costimulation signals from CD80/CD86 to CD28/CTLA-4 have been suggested to play an important role in the activation or inactivation of T lymphocytes.We investigated three polymorphic regions within the CTLA-4 gene, a C/T base exchange in the promoter region -318 (CTLA-4 -318C/T), an A/G substitution in the exon 1 position 49 (CTLA-4 49A/G), an (AT)(n) repeat polymorphism in the 3' untranslated region of exon 4 [CTLA-4 3' (AT)(n)], and a CD28 gene polymorphism, a T/C substitution in the intron 3 position +17 (CD28 IVS3+17T/C), in SLE patients and controls.SLE patients had significantly higher frequencies of the CTLA-4 49G allele (P=0.003) and of the CTLA-4 (AT)(n) 106 bp allele (P=0.0008) than controls. We also found a strong linkage disequilibrium between the A allele of CTLA-4 49A/G and the 86 bp allele of CTLA-4 3' (AT)(n). On the contrary, no association was found between SLE and CTLA-4 -318C/T or CD28 IVS3 +17T/C.We conclude that the CTLA-4 gene appears to play a significant role in the development of SLE in the Japanese population." @default.
• W2134927256 created "2016-06-24" @default.
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• W2134927256 date "2001-06-01" @default.
• W2134927256 modified "2023-10-01" @default.
• W2134927256 title "Association of CTLA‐4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population" @default.
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• W2134927256 doi "https://doi.org/10.1093/rheumatology/40.6.662" @default.
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