Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134928197> ?p ?o ?g. }
- W2134928197 endingPage "63" @default.
- W2134928197 startingPage "57" @default.
- W2134928197 abstract "The association of human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) has been supported by several immunological and molecular studies. Recently, membrane cofactor protein (CD46) has been identified as the cellular receptor for the A and B variants of HHV-6. Elevated levels of soluble CD46 (sCD46) have been reported in the serum and CSF of MS patients. The aim of this study was to investigate a possible correlation between elevated levels of soluble CD46 and the presence of serum HHV-6 DNA in MS patients. An immunoaffinity column comprised of immobilized monoclonal antibodies to CD46 was developed to isolate sCD46 from cell free body fluids of MS patients and controls. After immunoaffinity purification, DNA was extracted from anti-CD46 column eluates and subjected to PCR amplification. Of the 42 MS samples tested, 4 serum samples were HHV-6 positive, 3 of which were typed as HHV-6A. The co-purification of sCD46 and HHV-6 DNA from MS sera indicates that HHV-6 is tightly connected to its receptor, CD46, in the serum of MS patients." @default.
- W2134928197 created "2016-06-24" @default.
- W2134928197 creator A5001176813 @default.
- W2134928197 creator A5013318156 @default.
- W2134928197 creator A5016198755 @default.
- W2134928197 creator A5041150149 @default.
- W2134928197 creator A5051578610 @default.
- W2134928197 creator A5052362906 @default.
- W2134928197 creator A5079246454 @default.
- W2134928197 date "2005-06-01" @default.
- W2134928197 modified "2023-10-01" @default.
- W2134928197 title "Co-purification of soluble membrane cofactor protein (CD46) and human herpesvirus 6 variant A genome in serum from multiple sclerosis patients" @default.
- W2134928197 cites W1845094941 @default.
- W2134928197 cites W1899355786 @default.
- W2134928197 cites W1964524014 @default.
- W2134928197 cites W1969929508 @default.
- W2134928197 cites W1973290618 @default.
- W2134928197 cites W1973331666 @default.
- W2134928197 cites W1984019715 @default.
- W2134928197 cites W1985844089 @default.
- W2134928197 cites W1986224730 @default.
- W2134928197 cites W1989186015 @default.
- W2134928197 cites W1989716037 @default.
- W2134928197 cites W2003730176 @default.
- W2134928197 cites W2012365353 @default.
- W2134928197 cites W2018027744 @default.
- W2134928197 cites W2021222563 @default.
- W2134928197 cites W2027962748 @default.
- W2134928197 cites W2031235389 @default.
- W2134928197 cites W2037796326 @default.
- W2134928197 cites W2042288895 @default.
- W2134928197 cites W2044848371 @default.
- W2134928197 cites W2045635956 @default.
- W2134928197 cites W2049021121 @default.
- W2134928197 cites W2051606776 @default.
- W2134928197 cites W2059250207 @default.
- W2134928197 cites W2060773611 @default.
- W2134928197 cites W2074833470 @default.
- W2134928197 cites W2078698376 @default.
- W2134928197 cites W2083736060 @default.
- W2134928197 cites W2102554655 @default.
- W2134928197 cites W2104913286 @default.
- W2134928197 cites W2108658900 @default.
- W2134928197 cites W2115892914 @default.
- W2134928197 cites W2116405687 @default.
- W2134928197 cites W2116736809 @default.
- W2134928197 cites W2144118158 @default.
- W2134928197 cites W2154937322 @default.
- W2134928197 cites W2156486655 @default.
- W2134928197 cites W2161497718 @default.
- W2134928197 doi "https://doi.org/10.1016/j.virusres.2005.01.005" @default.
- W2134928197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15845255" @default.
- W2134928197 hasPublicationYear "2005" @default.
- W2134928197 type Work @default.
- W2134928197 sameAs 2134928197 @default.
- W2134928197 citedByCount "32" @default.
- W2134928197 countsByYear W21349281972012 @default.
- W2134928197 countsByYear W21349281972013 @default.
- W2134928197 countsByYear W21349281972014 @default.
- W2134928197 countsByYear W21349281972016 @default.
- W2134928197 countsByYear W21349281972017 @default.
- W2134928197 countsByYear W21349281972020 @default.
- W2134928197 countsByYear W21349281972023 @default.
- W2134928197 crossrefType "journal-article" @default.
- W2134928197 hasAuthorship W2134928197A5001176813 @default.
- W2134928197 hasAuthorship W2134928197A5013318156 @default.
- W2134928197 hasAuthorship W2134928197A5016198755 @default.
- W2134928197 hasAuthorship W2134928197A5041150149 @default.
- W2134928197 hasAuthorship W2134928197A5051578610 @default.
- W2134928197 hasAuthorship W2134928197A5052362906 @default.
- W2134928197 hasAuthorship W2134928197A5079246454 @default.
- W2134928197 hasConcept C111684460 @default.
- W2134928197 hasConcept C153911025 @default.
- W2134928197 hasConcept C159047783 @default.
- W2134928197 hasConcept C159654299 @default.
- W2134928197 hasConcept C170493617 @default.
- W2134928197 hasConcept C203014093 @default.
- W2134928197 hasConcept C2522874641 @default.
- W2134928197 hasConcept C2776409557 @default.
- W2134928197 hasConcept C2777399126 @default.
- W2134928197 hasConcept C2780640218 @default.
- W2134928197 hasConcept C2780727368 @default.
- W2134928197 hasConcept C542903549 @default.
- W2134928197 hasConcept C552990157 @default.
- W2134928197 hasConcept C55493867 @default.
- W2134928197 hasConcept C86803240 @default.
- W2134928197 hasConcept C92731135 @default.
- W2134928197 hasConceptScore W2134928197C111684460 @default.
- W2134928197 hasConceptScore W2134928197C153911025 @default.
- W2134928197 hasConceptScore W2134928197C159047783 @default.
- W2134928197 hasConceptScore W2134928197C159654299 @default.
- W2134928197 hasConceptScore W2134928197C170493617 @default.
- W2134928197 hasConceptScore W2134928197C203014093 @default.
- W2134928197 hasConceptScore W2134928197C2522874641 @default.
- W2134928197 hasConceptScore W2134928197C2776409557 @default.
- W2134928197 hasConceptScore W2134928197C2777399126 @default.
- W2134928197 hasConceptScore W2134928197C2780640218 @default.
- W2134928197 hasConceptScore W2134928197C2780727368 @default.