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• W2134936194 abstract "We designed a supramolecular curcumin vesicle based on different curcumin-cyclodextrin amphiphiles, which could greatly enhance the aqueous solubility of curcumin up to 7000-fold. The vesicles existed for about one month in aqueous solution at around 20 °C, showing a certain colloidal stability. Curcumin vesicles were also prepared when different host molecules were employed as the hydrophilic heads of the supramolecular amphiphiles. Finally, curcumin could be controllably released with the disruption of the vesicles when the external stimuli, including competitive guest molecules, enzymes and copper ions were added into the vesicles system. • A supramolecular curcumin vesicle, which can greatly enhance curcumin solubility, is prepared by different cyclodextrins and curcumin in aqueous solution. • The morphologies and sizes of the vesicles were identified by TEM, SEM, AFM and DLS. • The mechanism of the vesicle formation was studied with various methods. • Curcumin could be controllably released by the addition of external stimuli into the vesicle solution. Curcumin is a safe and nontoxic natural potential antitumor drug. However, its extremely low aqueous solubility severely limits its clinical application. We designed a supramolecular curcumin vesicle based on different curcumin-cyclodextrin amphiphiles, which could greatly enhance the aqueous solubility of curcumin up to 7000-fold. The vesicles can exist for about one month in aqueous solution at around 20 °C, showing a certain colloidal stability. The curcumin-β-cyclodextrin vesicles were identified by transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), and dynamic light scattering (DLS). X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), UV–vis spectrum and 1 H NMR were further employed to study the formation mechanism of the vesicles. Curcumin vesicles were also prepared when different host molecules were employed as the hydrophilic heads of the supramolecular amphiphiles. Finally, curcumin could be controllably released with the disruption of the vesicles when the external stimuli, including competitive guest molecules, enzymes and copper ions were added into the vesicles system." @default.
• W2134936194 created "2016-06-24" @default.
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• W2134936194 date "2014-10-01" @default.
• W2134936194 modified "2023-09-23" @default.
• W2134936194 title "A supramolecular curcumin vesicle and its application in controlling curcumin release" @default.
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• W2134936194 doi "https://doi.org/10.1016/j.colsurfa.2014.06.043" @default.
• W2134936194 hasPublicationYear "2014" @default.
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