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• W2134938035 abstract "ABSTRACT Actinobacillus pleuropneumoniae is a gram-negative bacterial pathogen that causes a severe hemorrhagic pneumonia in swine. We have previously shown that the limitation of branched-chain amino acids (BCAAs) is a cue that induces the expression of a subset of A. pleuropneumoniae genes identified as specifically induced during infection of the natural host animal by using an in vivo expression technology screen. Leucine-responsive regulatory protein (Lrp) is a global regulator and has been shown in Escherichia coli to regulate many genes, including genes involved in BCAA biosynthesis. We hypothesized that A. pleuropneumoniae contains a regulator similar to Lrp and that this protein is involved in the regulation of a subset of genes important during infection and recently shown to have increased expression in the absence of BCAAs. We report the identification of an A. pleuropneumoniae serotype 1 gene encoding a protein with similarity to amino acid sequence and functional domains of other reported Lrp proteins. We further show that purified A. pleuropneumoniae His 6 -Lrp binds in vitro to the A. pleuropneumoniae promoter regions for ilvI , antisense cps1AB , lrp , and nqr . A genetically defined A. pleuropneumoniae lrp mutant was constructed using an allelic replacement and sucrose counterselection method. Analysis of expression from the ilvI and antisense cps1AB promoters in wild-type, lrp mutant, and complemented lrp mutant strains indicated that Lrp is required for induction of expression of ilvI under BCAA limitation." @default.
• W2134938035 created "2016-06-24" @default.
• W2134938035 creator A5063801254 @default.
• W2134938035 creator A5091789336 @default.
• W2134938035 date "2007-01-01" @default.
• W2134938035 modified "2023-09-26" @default.
• W2134938035 title "Identification of the <i>Actinobacillus pleuropneumoniae</i> Leucine-Responsive Regulatory Protein and Its Involvement in the Regulation of In Vivo-Induced Genes" @default.
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• W2134938035 doi "https://doi.org/10.1128/iai.00120-06" @default.
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