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• W2134942012 abstract "Microsomal enzyme induction, a term denoting the ability of the substrate for a microsomal enzyme to enhance the activity of that enzyme and frequently of related enzymes, has been demonstrated in a wide range of tissues, notably the liver, placenta, small intestinal muccosa, and peripheral lymphocytes. The major agents that cause microsomal enzyme induction are drugs and xenobiotics. Factors modulating the extent of enzyme induction by a given agent include age and nutrition, and wide species variations are encountered with different inducing agents. Markers for microsomal enzyme induction include determination of the plasma half-life for conveniently measured drugs, and the measurement of endogenous metabolites such as 6;-hydroxycortisol and D-glucaric acid in 24-h urine collections. While these are valuable for monitoring enzyme induction in healthy patients, they are altered in certain forms of liver disease, and results must then be interpreted with caution. Microsomal enzyme induction may interfere with reference values, particularly for membrane-bound enzymes, in otherwise healthy populations, and may play a role in metabolic bone disease, drug interactions, carcinogenesis, and hypertriglyceridemia. Drug therapy of the neonatal and congenital hyperbilirubinemias has been inspired by the mechanism of hepatic microsomal enzyme induction, and ''markers'' for enzyme induction can be used tomore » monitor drug compliance. The activity of serum <-glutamyltransferase seems to be especially valuable for this purpose.« less" @default.
• W2134942012 created "2016-06-24" @default.
• W2134942012 creator A5003387956 @default.
• W2134942012 date "1980-05-01" @default.
• W2134942012 modified "2023-10-17" @default.
• W2134942012 title "The expanding role of microsomal enzyme induction, and its implications for clinical chemistry." @default.
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• W2134942012 cites W1543122733 @default.
• W2134942012 cites W1635676915 @default.
• W2134942012 cites W1701599069 @default.
• W2134942012 cites W1910350416 @default.
• W2134942012 cites W1942211023 @default.
• W2134942012 cites W1963548376 @default.
• W2134942012 cites W1966229631 @default.
• W2134942012 cites W1975621468 @default.
• W2134942012 cites W1975957728 @default.
• W2134942012 cites W1976696090 @default.
• W2134942012 cites W1977593695 @default.
• W2134942012 cites W1979060800 @default.
• W2134942012 cites W1981976080 @default.
• W2134942012 cites W1983808158 @default.
• W2134942012 cites W1989611565 @default.
• W2134942012 cites W1991091467 @default.
• W2134942012 cites W1994462177 @default.
• W2134942012 cites W1996215212 @default.
• W2134942012 cites W2002546431 @default.
• W2134942012 cites W2002808335 @default.
• W2134942012 cites W2004835857 @default.
• W2134942012 cites W2007932634 @default.
• W2134942012 cites W2014285845 @default.
• W2134942012 cites W2015350995 @default.
• W2134942012 cites W2017483927 @default.
• W2134942012 cites W2023198078 @default.
• W2134942012 cites W2024836835 @default.
• W2134942012 cites W2032252383 @default.
• W2134942012 cites W2034393186 @default.
• W2134942012 cites W2036181145 @default.
• W2134942012 cites W2038861520 @default.
• W2134942012 cites W2039289626 @default.
• W2134942012 cites W2043210773 @default.
• W2134942012 cites W2048719416 @default.
• W2134942012 cites W2050102180 @default.
• W2134942012 cites W2059466422 @default.
• W2134942012 cites W2059688970 @default.
• W2134942012 cites W2061104170 @default.
• W2134942012 cites W2063849519 @default.
• W2134942012 cites W2064726653 @default.
• W2134942012 cites W2079008582 @default.
• W2134942012 cites W2079912330 @default.
• W2134942012 cites W2081558537 @default.
• W2134942012 cites W2085887263 @default.
• W2134942012 cites W2088665131 @default.
• W2134942012 cites W2092076217 @default.
• W2134942012 cites W2092533217 @default.
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• W2134942012 cites W2111332473 @default.
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• W2134942012 cites W2167330497 @default.
• W2134942012 cites W2168604736 @default.
• W2134942012 cites W2182446543 @default.
• W2134942012 cites W2233776082 @default.
• W2134942012 cites W2235916215 @default.
• W2134942012 cites W227721353 @default.
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• W2134942012 cites W2342178420 @default.
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• W2134942012 doi "https://doi.org/10.1093/clinchem/26.6.691" @default.
• W2134942012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6989516" @default.
• W2134942012 hasPublicationYear "1980" @default.
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