Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134944658> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2134944658 endingPage "2028" @default.
- W2134944658 startingPage "2026" @default.
- W2134944658 abstract "Nikkomycin Z is a chitin synthetase inhibitor. In vitro, nikkomycin Z had good activity against Blastomyces dermatitidis, with an MIC of 0.78 microg/ml and a minimal fungicidal concentration of 3.1 microg/ml. The efficacies of various treatment durations (3, 5, or 10 days) and doses (200, 400, or 1,000 mg/kg of body weight) of nikkomycin Z given twice daily were compared with those of itraconazole at 200 mg/kg given twice daily and amphotericin B at 6.25 mg/kg in a murine model of pulmonary blastomycosis. All treatments prolonged survival compared with untreated controls (P < 0.05 to 0.01); 100% survival was achieved with 5 or 10 days of any nikkomycin Z dose or with amphotericin B. Amphotericin B and nikkomycin Z, but not itraconazole, reduced infection compared with controls. Amphotericin B and the 10-day regimens of all nikkomycin Z doses were equivalent and superior to itraconazole or nikkomycin Z for < or = 5 days at any dose (P < 0.05 to 0.01). Increased duration and/or dosage improved the efficacy of nikkomycin Z, with 10 days of each dose curing 50 to 90% of the animals. Only a 1,000-mg/kg/day dose of nikkomycin Z was curative when treatment lasted less than 10 days. In contrast, itraconazole cured no mice, while amphotericin B cured all mice. Based on the total amount of drug given, amphotericin B was estimated to be 32 times as active as nikkomycin Z and nikkomycin Z was estimated to be 3 times as active as itraconazole. Overall, nikkomycin Z given orally was well tolerated, had good activity against blastomycosis, and could result in biological cure, thus producing results equivalent to those of parenteral amphotericin B." @default.
- W2134944658 created "2016-06-24" @default.
- W2134944658 creator A5014273536 @default.
- W2134944658 creator A5021143803 @default.
- W2134944658 date "1997-09-01" @default.
- W2134944658 modified "2023-10-02" @default.
- W2134944658 title "Efficacy of nikkomycin Z against experimental pulmonary blastomycosis" @default.
- W2134944658 cites W1964180283 @default.
- W2134944658 cites W1982156664 @default.
- W2134944658 cites W2004523917 @default.
- W2134944658 cites W2046045366 @default.
- W2134944658 cites W2059402296 @default.
- W2134944658 cites W2079407276 @default.
- W2134944658 cites W2140861705 @default.
- W2134944658 cites W2166675124 @default.
- W2134944658 doi "https://doi.org/10.1128/aac.41.9.2026" @default.
- W2134944658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/164059" @default.
- W2134944658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9303408" @default.
- W2134944658 hasPublicationYear "1997" @default.
- W2134944658 type Work @default.
- W2134944658 sameAs 2134944658 @default.
- W2134944658 citedByCount "50" @default.
- W2134944658 countsByYear W21349446582012 @default.
- W2134944658 countsByYear W21349446582013 @default.
- W2134944658 countsByYear W21349446582016 @default.
- W2134944658 countsByYear W21349446582017 @default.
- W2134944658 countsByYear W21349446582018 @default.
- W2134944658 countsByYear W21349446582020 @default.
- W2134944658 countsByYear W21349446582021 @default.
- W2134944658 countsByYear W21349446582023 @default.
- W2134944658 crossrefType "journal-article" @default.
- W2134944658 hasAuthorship W2134944658A5014273536 @default.
- W2134944658 hasAuthorship W2134944658A5021143803 @default.
- W2134944658 hasBestOaLocation W21349446581 @default.
- W2134944658 hasConcept C185592680 @default.
- W2134944658 hasConcept C203014093 @default.
- W2134944658 hasConcept C2777071850 @default.
- W2134944658 hasConcept C2779548794 @default.
- W2134944658 hasConcept C2779602430 @default.
- W2134944658 hasConcept C2779629538 @default.
- W2134944658 hasConcept C71924100 @default.
- W2134944658 hasConcept C86803240 @default.
- W2134944658 hasConcept C89423630 @default.
- W2134944658 hasConcept C98274493 @default.
- W2134944658 hasConceptScore W2134944658C185592680 @default.
- W2134944658 hasConceptScore W2134944658C203014093 @default.
- W2134944658 hasConceptScore W2134944658C2777071850 @default.
- W2134944658 hasConceptScore W2134944658C2779548794 @default.
- W2134944658 hasConceptScore W2134944658C2779602430 @default.
- W2134944658 hasConceptScore W2134944658C2779629538 @default.
- W2134944658 hasConceptScore W2134944658C71924100 @default.
- W2134944658 hasConceptScore W2134944658C86803240 @default.
- W2134944658 hasConceptScore W2134944658C89423630 @default.
- W2134944658 hasConceptScore W2134944658C98274493 @default.
- W2134944658 hasIssue "9" @default.
- W2134944658 hasLocation W21349446581 @default.
- W2134944658 hasLocation W21349446582 @default.
- W2134944658 hasLocation W21349446583 @default.
- W2134944658 hasLocation W21349446584 @default.
- W2134944658 hasOpenAccess W2134944658 @default.
- W2134944658 hasPrimaryLocation W21349446581 @default.
- W2134944658 hasRelatedWork W173978332 @default.
- W2134944658 hasRelatedWork W1984227450 @default.
- W2134944658 hasRelatedWork W2060357610 @default.
- W2134944658 hasRelatedWork W2095728513 @default.
- W2134944658 hasRelatedWork W2102587738 @default.
- W2134944658 hasRelatedWork W2135943585 @default.
- W2134944658 hasRelatedWork W2404027193 @default.
- W2134944658 hasRelatedWork W2413083565 @default.
- W2134944658 hasRelatedWork W2419151051 @default.
- W2134944658 hasRelatedWork W4300008328 @default.
- W2134944658 hasVolume "41" @default.
- W2134944658 isParatext "false" @default.
- W2134944658 isRetracted "false" @default.
- W2134944658 magId "2134944658" @default.
- W2134944658 workType "article" @default.