FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134955467> ?p ?o ?g. }

• W2134955467 endingPage "40" @default.
• W2134955467 startingPage "35" @default.
• W2134955467 abstract "The purpose of this randomized trial was to confirm drug safety and to obtain preliminary efficacy data on Cervene (nalmefene), an opioid antagonist with relative kappa receptor selectivity, for the treatment of acute ischemic stroke. Patients were treated for 24 hours with either intravenous Cervene (0.05 mg/kg as an initial infusion over 15 minutes and 0.01 mg/kg/h maintenance) or placebo within 6 hours of an ischemic stroke. Efficacy was assessed by comparing the change from baseline to day 7 in the National Institutes of Health stroke scale score (NIHSSS) and the Glasgow Outcome Scale and Barthel Index at 3 months. Forty-four evaluable patients were randomized (3:1) to Cervene (n = 34; treated at 5.0 +/- 0.9 hours after onset) and placebo (n = 10; treated at 4.6 +/- 1.5 hours). No deaths or serious adverse events reasonably attributable to Cervene have been reported. A major improvement (NHSSS > 4) was seen at day 7: placebo, 33% (three of nine patients) and Cervene, 66% (19 of 29 patients). Only patients with initial NIHSSS >/= 4 were considered evaluable for this primary endpoint. Good recovery at 3 months (Glasgow = 5) was as follows: placebo, 50% (5 of 10 patients) and Cervene, 73% (24 of 33 patients). The death rate at 3 months was placebo, 20% (2 of 10 patients) and Cervene, 9.1% (3 of 33 patients). One patient was lost to follow-up. In conclusion, results from this randomized trial suggest that Cervene is safe, tolerable, and may be beneficial in the treatment of acute stroke patients." @default.
• W2134955467 created "2016-06-24" @default.
• W2134955467 creator A5001304844 @default.
• W2134955467 creator A5003394099 @default.
• W2134955467 creator A5008726438 @default.
• W2134955467 creator A5024270531 @default.
• W2134955467 creator A5039140268 @default.
• W2134955467 creator A5046138159 @default.
• W2134955467 creator A5055439990 @default.
• W2134955467 creator A5072876748 @default.
• W2134955467 creator A5076884809 @default.
• W2134955467 creator A5079558294 @default.
• W2134955467 creator A5087028329 @default.
• W2134955467 creator A5089738484 @default.
• W2134955467 date "1996-09-01" @default.
• W2134955467 modified "2023-10-17" @default.
• W2134955467 title "Randomized trial of cervene, a κ receptor-selective opioid antagonist, in acute ischemic stroke" @default.
• W2134955467 cites W1968205083 @default.
• W2134955467 cites W1970029670 @default.
• W2134955467 cites W1981992968 @default.
• W2134955467 cites W1986343337 @default.
• W2134955467 cites W1995514548 @default.
• W2134955467 cites W2008443071 @default.
• W2134955467 cites W2026918087 @default.
• W2134955467 cites W2027123157 @default.
• W2134955467 cites W2039392119 @default.
• W2134955467 cites W2042550512 @default.
• W2134955467 cites W2044547224 @default.
• W2134955467 cites W2051572660 @default.
• W2134955467 cites W2070949149 @default.
• W2134955467 cites W2079882374 @default.
• W2134955467 cites W2087046456 @default.
• W2134955467 cites W2108803055 @default.
• W2134955467 cites W2109708478 @default.
• W2134955467 cites W2113920766 @default.
• W2134955467 cites W2162840262 @default.
• W2134955467 cites W4300539464 @default.
• W2134955467 doi "https://doi.org/10.1016/s1052-3057(96)80024-3" @default.
• W2134955467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17894963" @default.
• W2134955467 hasPublicationYear "1996" @default.
• W2134955467 type Work @default.
• W2134955467 sameAs 2134955467 @default.
• W2134955467 citedByCount "15" @default.
• W2134955467 countsByYear W21349554672015 @default.
• W2134955467 countsByYear W21349554672019 @default.
• W2134955467 countsByYear W21349554672020 @default.
• W2134955467 countsByYear W21349554672021 @default.
• W2134955467 countsByYear W21349554672022 @default.
• W2134955467 crossrefType "journal-article" @default.
• W2134955467 hasAuthorship W2134955467A5001304844 @default.
• W2134955467 hasAuthorship W2134955467A5003394099 @default.
• W2134955467 hasAuthorship W2134955467A5008726438 @default.
• W2134955467 hasAuthorship W2134955467A5024270531 @default.
• W2134955467 hasAuthorship W2134955467A5039140268 @default.
• W2134955467 hasAuthorship W2134955467A5046138159 @default.
• W2134955467 hasAuthorship W2134955467A5055439990 @default.
• W2134955467 hasAuthorship W2134955467A5072876748 @default.
• W2134955467 hasAuthorship W2134955467A5076884809 @default.
• W2134955467 hasAuthorship W2134955467A5079558294 @default.
• W2134955467 hasAuthorship W2134955467A5087028329 @default.
• W2134955467 hasAuthorship W2134955467A5089738484 @default.
• W2134955467 hasConcept C126322002 @default.
• W2134955467 hasConcept C127413603 @default.
• W2134955467 hasConcept C142724271 @default.
• W2134955467 hasConcept C168563851 @default.
• W2134955467 hasConcept C170493617 @default.
• W2134955467 hasConcept C197934379 @default.
• W2134955467 hasConcept C203092338 @default.
• W2134955467 hasConcept C204787440 @default.
• W2134955467 hasConcept C27081682 @default.
• W2134955467 hasConcept C2780645631 @default.
• W2134955467 hasConcept C2781063702 @default.
• W2134955467 hasConcept C42219234 @default.
• W2134955467 hasConcept C71924100 @default.
• W2134955467 hasConcept C78519656 @default.
• W2134955467 hasConceptScore W2134955467C126322002 @default.
• W2134955467 hasConceptScore W2134955467C127413603 @default.
• W2134955467 hasConceptScore W2134955467C142724271 @default.
• W2134955467 hasConceptScore W2134955467C168563851 @default.
• W2134955467 hasConceptScore W2134955467C170493617 @default.
• W2134955467 hasConceptScore W2134955467C197934379 @default.
• W2134955467 hasConceptScore W2134955467C203092338 @default.
• W2134955467 hasConceptScore W2134955467C204787440 @default.
• W2134955467 hasConceptScore W2134955467C27081682 @default.
• W2134955467 hasConceptScore W2134955467C2780645631 @default.
• W2134955467 hasConceptScore W2134955467C2781063702 @default.
• W2134955467 hasConceptScore W2134955467C42219234 @default.
• W2134955467 hasConceptScore W2134955467C71924100 @default.
• W2134955467 hasConceptScore W2134955467C78519656 @default.
• W2134955467 hasIssue "1" @default.
• W2134955467 hasLocation W21349554671 @default.
• W2134955467 hasLocation W21349554672 @default.
• W2134955467 hasOpenAccess W2134955467 @default.
• W2134955467 hasPrimaryLocation W21349554671 @default.
• W2134955467 hasRelatedWork W2100677424 @default.
• W2134955467 hasRelatedWork W2559946394 @default.
• W2134955467 hasRelatedWork W2766008196 @default.
• W2134955467 hasRelatedWork W3007053288 @default.

• next