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• W2134956543 abstract "You have accessJournal of UrologyTechnology & Instruments: Laparoscopy - Malignant Disease1 Apr 2012850 OPTIMIZING ARRAY-BASED DELIVERY OF PHOTODYNAMIC THERAPY TO SOLID ORGANS IN A LARGE ANIMAL MODEL Simon Kimm, MD Tatum Tarin, MD Philip Zhao, MD Avigdor Scherz, andPhD Jonathan ColemanMD Simon KimmSimon Kimm New York, NY More articles by this author , Tatum TarinTatum Tarin New York, NY More articles by this author , Philip ZhaoPhilip Zhao New York, NY More articles by this author , Avigdor ScherzAvigdor Scherz Rehovot, Israel More articles by this author , and Jonathan ColemanJonathan Coleman New York, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.942AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Photodynamic therapy (PDT) requires the delivery of specific laser energies to tissues exposed to a systemically administered photosensitizing agent. Light is typically delivered through arrays of cylindrical diffusers, with the largest such experience in the human and canine prostate. The performance of these cylindrical diffusers in other organs and tissue types is not well defined. Physical properties that influence the absorption and scattering of light, and physiologic properties such as perfusion and collateral blood flow can alter the treatment effect of PDT in different tissues. We aimed to characterize the size and extent of PDT effects in multiple tissue types at different laser energies. METHODS 15 female Yorkshire pigs were used after approval by the Memorial Sloan-Kettering Cancer Center Institutional Animal Care and Use Committee. Cylindrical diffusers (10 to 20mm) were deployed in the parenchyma of the kidney and liver using standardized templates in arrays of three and four laser fibers. 4mg/kg of WST-11 was infused over 10 minutes in the treatment arm, with no drug administered in sham animals. A laser fluence of 75mW/cm, 105mW/cm, and 208mW/cm was applied to each tissue type for a duration of 20 minutes. Temperature and light-dosimeter data were collected. Animals were euthanized 4 hours post-procedure and specimens were collected for gross and histologic examination. RESULTS Distinct areas of effect were seen in tissues at 4 hours after PDT for each laser energy level. Such effects were not observed in sham studies. For the liver, the mean radius of the effect area was 0.33, 0.40, and 0.55cm at 75, 105, and 208mW/cm, respectively. These differences were statistically significant (208 vs. 75mW/cm: p=0.004, 208 vs. 105mW/cm: p=0.0001, and 105 vs. 75mW/cm: p=0.02). For the kidney, the mean radius was 0.30, 0.35, and 0.65cm at 75, 105, and 208mW/cm, respectively. Statistical significance was seen between the 208 and 105mW/cm tissue groups (p=0.04). Dosimetery data collected during PDT correlated well with the gross pathologic area of effect. CONCLUSIONS Cylindrical diffusers of varying length and laser fluence produced significantly different areas of effect when arrayed in porcine solid organs. These observed differences will have a significant impact on the deployment of laser fibers to produce maximal and consistent tissue effects. Systematic characterization of these effects is necessary in optimizing array-based delivery of this therapy to different tissue types. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e346 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Simon Kimm New York, NY More articles by this author Tatum Tarin New York, NY More articles by this author Philip Zhao New York, NY More articles by this author Avigdor Scherz Rehovot, Israel More articles by this author Jonathan Coleman New York, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2134956543 title "850 OPTIMIZING ARRAY-BASED DELIVERY OF PHOTODYNAMIC THERAPY TO SOLID ORGANS IN A LARGE ANIMAL MODEL" @default.
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