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- W2134966512 abstract "The functional impact of adult-generated granule cells in the epileptic brain is unclear, with data supporting both protective and maladaptive roles. These conflicting findings could be explained if new granule cells integrate heterogeneously, with some cells taking neutral or adaptive roles and others contributing to recurrent circuitry supporting seizures. Here, we tested this hypothesis by completing detailed morphological characterizations of age- and experience-defined cohorts of adult-generated granule cells from transgenic mice. The majority of newborn cells exposed to an epileptogenic insult exhibited reductions in dendritic spine number, suggesting reduced excitatory input to these cells. A significant subset, however, exhibited higher spine numbers. These latter cells tended to have enlarged cell bodies, long basal dendrites, or both. Moreover, cells with basal dendrites received significantly more recurrent mossy fiber input through their apical dendrites, indicating that these cells are robustly integrated into the pathological circuitry of the epileptic brain. These data imply that newborn cells play complex--and potentially conflicting--roles in epilepsy." @default.
- W2134966512 created "2016-06-24" @default.
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- W2134966512 creator A5057901652 @default.
- W2134966512 creator A5059697093 @default.
- W2134966512 date "2011-01-05" @default.
- W2134966512 modified "2023-09-26" @default.
- W2134966512 title "Heterogeneous Integration of Adult-Generated Granule Cells into the Epileptic Brain" @default.
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- W2134966512 cites W1530683023 @default.
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- W2134966512 cites W1883162734 @default.
- W2134966512 cites W1963940970 @default.
- W2134966512 cites W1971275801 @default.
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- W2134966512 cites W1977662196 @default.
- W2134966512 cites W1985645482 @default.
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- W2134966512 cites W1994621830 @default.
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- W2134966512 cites W1998797350 @default.
- W2134966512 cites W2001904944 @default.
- W2134966512 cites W2002112050 @default.
- W2134966512 cites W2004018746 @default.
- W2134966512 cites W2006624547 @default.
- W2134966512 cites W2006985248 @default.
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- W2134966512 cites W2052935092 @default.
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- W2134966512 cites W2055625569 @default.
- W2134966512 cites W2056123267 @default.
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- W2134966512 cites W2151189924 @default.
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- W2134966512 cites W2162347476 @default.
- W2134966512 cites W2166711840 @default.
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- W2134966512 doi "https://doi.org/10.1523/jneurosci.2728-10.2011" @default.
- W2134966512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3022369" @default.
- W2134966512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21209195" @default.
- W2134966512 hasPublicationYear "2011" @default.
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