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- W2134988368 abstract "Background Several studies acknowledge the importance of inflammation in the development of COPD. However, regarding potential systemic inflammatory biomarkers that may correlate to disease severity, more studies are needed. Aim The aim was to assess the relationships between FEV1, COPD, CPC (chronic productive cough) and two putative inflammatory biomarkers in blood plasma. Methods The OLIN COPD study comprised 993 subjects with FEV1/FVC Results MMP-9 was significantly higher in COPD compared with non-COPD (median 612 vs. 550 ng/ml; p=0.029). In univariate analysis, FEV1 (% predicted) was inversely associated with MMP-9 (r=-0.141; p= Conclusions Results indicated that MMP-9 was increased in COPD and inversely related to FEV1. MMP-9 levels were further increased in COPD patients with CPC, indicating an enhanced systemic inflammatory response in patients with a bronchitic phenotype and thus, an increased risk of exacerbations. Additional analysis will contribute to the evaluation of these biomarkers in relation to other predictors and to disease severity in COPD." @default.
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- W2134988368 date "2013-09-01" @default.
- W2134988368 modified "2023-09-27" @default.
- W2134988368 title "Plasma MMP-9 is related to a bronchitic COPD phenotype - Report from the obstructive lung disease in Northern Sweden (OLIN) studies" @default.
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