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• W2134996831 startingPage "277" @default.
• W2134996831 abstract "Prior to the advent of nuclear magnetic resonance (NMR) spectroscopy, human glucose metabolism was studied through tracer and tissue biopsy methodology. NMR spectroscopy now provides a noninvasive means to monitor metabolic flux and intracellular metabolite concentrations continuously. 13C NMR spectroscopy has shown that muscle glycogen synthesis accounts for the majority of insulin-stimulated muscle glucose uptake in normal volunteers and that defects in this process are chiefly responsible for insulin resistance in type 1 and type 2 diabetes mellitus, as well as in other insulin resistant states (obesity, insulin-resistant offspring of type 2 diabetic parents, elevation of plasma FFA concentrations). Furthermore, using 31P NMR spectroscopy to measure intracellular glucose-6-phosphate, it has been shown that defects in insulin-stimulated glucose transport/phosphorylation activity are primarily responsible for the insulin resistance in these states." @default.
• W2134996831 created "2016-06-24" @default.
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• W2134996831 date "1999-02-01" @default.
• W2134996831 modified "2023-09-23" @default.
• W2134996831 title "Applications of NMR Spectroscopy to Study Muscle Glycogen Metabolism in Man" @default.
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• W2134996831 doi "https://doi.org/10.1146/annurev.med.50.1.277" @default.
• W2134996831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10073278" @default.
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