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• W2134996933 abstract "Neonates undergoing invasive procedures, postoperative pain or ventilatory support commonly receive opioids for treating pain and stress. Randomized clinical trials have examined the benefits and adverse effects of morphine or fentanyl for ventilated neonates and other indications. This paper summarizes the current evidence for opioid dosing in newborns, reviews their side-effects and explains the use of population kinetics and non-linear mixed-effects modeling to analyze the data from clinical trials. Opioid use should be reserved for severe pain postoperatively or during intensive care in neonates, using continuous infusions rather than intermittent boluses. The safety and efficacy data from prolonged opioid use, particularly on the long-term outcomes of neonates, is still lacking. The pharmacodynamics and pharmacogenetics of opioid use in infancy needs further investigation, using non-linear mixed-effects models to drive individualized therapy. The current interest in opioid research will reap rich dividends in providing pain relief for neonates and avoiding dangerous side effects." @default.
• W2134996933 created "2016-06-24" @default.
• W2134996933 creator A5066053988 @default.
• W2134996933 creator A5070760855 @default.
• W2134996933 date "2006-08-01" @default.
• W2134996933 modified "2023-10-02" @default.
• W2134996933 title "Pain control: Opioid dosing, population kinetics and side-effects" @default.
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• W2134996933 doi "https://doi.org/10.1016/j.siny.2006.02.008" @default.
• W2134996933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16621750" @default.
• W2134996933 hasPublicationYear "2006" @default.
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