FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135014769> ?p ?o ?g. }

• W2135014769 endingPage "250" @default.
• W2135014769 startingPage "241" @default.
• W2135014769 abstract "Viruses share antigenic sites with normal host cell components, a phenomenon known as molecular mimicry. It has long been suggested that viral infections might trigger an autoimmune response by several mechanisms including molecular mimicry. More than 600 antiviral monoclonal antibodies generated against 11 different viruses have been reported to react with 3.5% of cells specific for uninfected mouse organs. The main pathological feature of tropical spastic paraparesis/human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (TSP/HAM) is a chronic inflammation of the spinal cord characterized by perivascular cuffing of mononuclear cells accompanied by parenchymal lymphocytic infiltration. We detected the presence of autoantibodies against a 98- to 100-kDa protein of in vitro cultured human astrocytes and a 33- to 35-kDa protein from normal human brain in the serum of HTLV-I-seropositive individuals. The two cell proteins exhibited molecular mimicry with HTLV-I gag and tax proteins in TSP/HAM patients, respectively. Furthermore, the location of 33- to 35-kDa protein cross-reaction correlated with the anatomical spinal cord areas (in the rat model) in which axonal damage has been reported in several cases of TSP/HAM patients. Our experimental evidence strongly suggests that the demyelinating process occurring in TSP/HAM may be mediated by molecular mimicry between domains of some viral proteins and normal cellular targets of the spinal cord sections involved in the neurodegeneration." @default.
• W2135014769 created "2016-06-24" @default.
• W2135014769 creator A5016751271 @default.
• W2135014769 creator A5055333675 @default.
• W2135014769 creator A5077271051 @default.
• W2135014769 date "2005-02-01" @default.
• W2135014769 modified "2023-10-17" @default.
• W2135014769 title "Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy" @default.
• W2135014769 cites W1575515078 @default.
• W2135014769 cites W1964337760 @default.
• W2135014769 cites W1974516972 @default.
• W2135014769 cites W1977579938 @default.
• W2135014769 cites W1983973185 @default.
• W2135014769 cites W1990477022 @default.
• W2135014769 cites W1991533312 @default.
• W2135014769 cites W2001795328 @default.
• W2135014769 cites W2003290905 @default.
• W2135014769 cites W2003556197 @default.
• W2135014769 cites W2005149743 @default.
• W2135014769 cites W2014184887 @default.
• W2135014769 cites W2018244088 @default.
• W2135014769 cites W2021381133 @default.
• W2135014769 cites W2034930758 @default.
• W2135014769 cites W2036943819 @default.
• W2135014769 cites W2051035481 @default.
• W2135014769 cites W2052965892 @default.
• W2135014769 cites W2059729222 @default.
• W2135014769 cites W2074136122 @default.
• W2135014769 cites W2076758203 @default.
• W2135014769 cites W2076812487 @default.
• W2135014769 cites W2080672377 @default.
• W2135014769 cites W2081060219 @default.
• W2135014769 cites W2096428903 @default.
• W2135014769 cites W2109386393 @default.
• W2135014769 cites W2112218876 @default.
• W2135014769 cites W2119329692 @default.
• W2135014769 cites W2137162390 @default.
• W2135014769 cites W2137335452 @default.
• W2135014769 cites W2167211922 @default.
• W2135014769 doi "https://doi.org/10.1590/s0100-879x2005000200013" @default.
• W2135014769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15785836" @default.
• W2135014769 hasPublicationYear "2005" @default.
• W2135014769 type Work @default.
• W2135014769 sameAs 2135014769 @default.
• W2135014769 citedByCount "20" @default.
• W2135014769 countsByYear W21350147692012 @default.
• W2135014769 countsByYear W21350147692013 @default.
• W2135014769 countsByYear W21350147692014 @default.
• W2135014769 countsByYear W21350147692015 @default.
• W2135014769 countsByYear W21350147692017 @default.
• W2135014769 crossrefType "journal-article" @default.
• W2135014769 hasAuthorship W2135014769A5016751271 @default.
• W2135014769 hasAuthorship W2135014769A5055333675 @default.
• W2135014769 hasAuthorship W2135014769A5077271051 @default.
• W2135014769 hasBestOaLocation W21350147691 @default.
• W2135014769 hasConcept C142724271 @default.
• W2135014769 hasConcept C159047783 @default.
• W2135014769 hasConcept C159654299 @default.
• W2135014769 hasConcept C163764329 @default.
• W2135014769 hasConcept C169760540 @default.
• W2135014769 hasConcept C203014093 @default.
• W2135014769 hasConcept C2776392238 @default.
• W2135014769 hasConcept C2776925932 @default.
• W2135014769 hasConcept C2777119779 @default.
• W2135014769 hasConcept C2777604421 @default.
• W2135014769 hasConcept C2779134260 @default.
• W2135014769 hasConcept C2780130043 @default.
• W2135014769 hasConcept C2780775167 @default.
• W2135014769 hasConcept C542903549 @default.
• W2135014769 hasConcept C71924100 @default.
• W2135014769 hasConcept C86803240 @default.
• W2135014769 hasConceptScore W2135014769C142724271 @default.
• W2135014769 hasConceptScore W2135014769C159047783 @default.
• W2135014769 hasConceptScore W2135014769C159654299 @default.
• W2135014769 hasConceptScore W2135014769C163764329 @default.
• W2135014769 hasConceptScore W2135014769C169760540 @default.
• W2135014769 hasConceptScore W2135014769C203014093 @default.
• W2135014769 hasConceptScore W2135014769C2776392238 @default.
• W2135014769 hasConceptScore W2135014769C2776925932 @default.
• W2135014769 hasConceptScore W2135014769C2777119779 @default.
• W2135014769 hasConceptScore W2135014769C2777604421 @default.
• W2135014769 hasConceptScore W2135014769C2779134260 @default.
• W2135014769 hasConceptScore W2135014769C2780130043 @default.
• W2135014769 hasConceptScore W2135014769C2780775167 @default.
• W2135014769 hasConceptScore W2135014769C542903549 @default.
• W2135014769 hasConceptScore W2135014769C71924100 @default.
• W2135014769 hasConceptScore W2135014769C86803240 @default.
• W2135014769 hasIssue "2" @default.
• W2135014769 hasLocation W21350147691 @default.
• W2135014769 hasLocation W21350147692 @default.
• W2135014769 hasLocation W21350147693 @default.
• W2135014769 hasOpenAccess W2135014769 @default.
• W2135014769 hasPrimaryLocation W21350147691 @default.
• W2135014769 hasRelatedWork W2003472532 @default.
• W2135014769 hasRelatedWork W2042848281 @default.
• W2135014769 hasRelatedWork W2043564505 @default.
• W2135014769 hasRelatedWork W2060946936 @default.
• W2135014769 hasRelatedWork W2065920961 @default.

• next