FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135016962> ?p ?o ?g. }

• W2135016962 endingPage "1724" @default.
• W2135016962 startingPage "1715" @default.
• W2135016962 abstract "Group B Streptococcus (GBS) is a major cause of invasive bacterial infections in newborns and certain adult populations. Surface filamentous appendages known as pili have been recently identified in GBS. However, little is known about the role of these structures in disease pathogenesis. In this study we sought to probe potential functional role(s) of PilB, the major GBS pilus protein subunit, by coupling analysis of an isogenic GBS pilB knockout strain with heterologous expression of the pilB gene in the nonpathogenic bacterium Lactococcus lactis. We found the knockout GBS strain that lacked PilB was more susceptible than wild-type (WT) GBS to killing by isolated macrophages and neutrophils. Survival was linked to the ability of PilB to mediate GBS resistance to cathelicidin antimicrobial peptides. Furthermore, the PilB-deficient GBS mutant was more readily cleared from the mouse bloodstream and less-virulent in vivo compared to the WT parent strain. Strikingly, overexpression of the pilB gene alone in L..." @default.
• W2135016962 created "2016-06-24" @default.
• W2135016962 creator A5030470781 @default.
• W2135016962 creator A5037501365 @default.
• W2135016962 creator A5042304008 @default.
• W2135016962 creator A5054548078 @default.
• W2135016962 creator A5067852918 @default.
• W2135016962 creator A5070330260 @default.
• W2135016962 creator A5076276224 @default.
• W2135016962 date "2008-01-15" @default.
• W2135016962 modified "2023-10-15" @default.
• W2135016962 title "A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence" @default.
• W2135016962 cites W1518772404 @default.
• W2135016962 cites W1532555431 @default.
• W2135016962 cites W1535575371 @default.
• W2135016962 cites W1540464676 @default.
• W2135016962 cites W1550209178 @default.
• W2135016962 cites W1572509607 @default.
• W2135016962 cites W1870627579 @default.
• W2135016962 cites W1907886565 @default.
• W2135016962 cites W1915683180 @default.
• W2135016962 cites W1937123239 @default.
• W2135016962 cites W1964758221 @default.
• W2135016962 cites W1977820570 @default.
• W2135016962 cites W1978191506 @default.
• W2135016962 cites W1984500397 @default.
• W2135016962 cites W1996004548 @default.
• W2135016962 cites W1998712099 @default.
• W2135016962 cites W2007954929 @default.
• W2135016962 cites W2013674343 @default.
• W2135016962 cites W2039817895 @default.
• W2135016962 cites W2047438645 @default.
• W2135016962 cites W2052397091 @default.
• W2135016962 cites W2057162862 @default.
• W2135016962 cites W2060483617 @default.
• W2135016962 cites W2069940309 @default.
• W2135016962 cites W2085728487 @default.
• W2135016962 cites W2089726603 @default.
• W2135016962 cites W2097750123 @default.
• W2135016962 cites W2098863862 @default.
• W2135016962 cites W2108428287 @default.
• W2135016962 cites W2109276669 @default.
• W2135016962 cites W2110351640 @default.
• W2135016962 cites W2117422749 @default.
• W2135016962 cites W2119280787 @default.
• W2135016962 cites W2126306331 @default.
• W2135016962 cites W2130347853 @default.
• W2135016962 cites W2131589291 @default.
• W2135016962 cites W2133246684 @default.
• W2135016962 cites W2135211948 @default.
• W2135016962 cites W2138122846 @default.
• W2135016962 cites W2139049032 @default.
• W2135016962 cites W2141520935 @default.
• W2135016962 cites W2142748660 @default.
• W2135016962 cites W2148572341 @default.
• W2135016962 cites W2148634126 @default.
• W2135016962 cites W2149166316 @default.
• W2135016962 cites W2149757052 @default.
• W2135016962 cites W2150488998 @default.
• W2135016962 cites W2153126391 @default.
• W2135016962 cites W2162220384 @default.
• W2135016962 doi "https://doi.org/10.1096/fj.07-093963" @default.
• W2135016962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2721339" @default.
• W2135016962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18198218" @default.
• W2135016962 hasPublicationYear "2008" @default.
• W2135016962 type Work @default.
• W2135016962 sameAs 2135016962 @default.
• W2135016962 citedByCount "90" @default.
• W2135016962 countsByYear W21350169622012 @default.
• W2135016962 countsByYear W21350169622013 @default.
• W2135016962 countsByYear W21350169622014 @default.
• W2135016962 countsByYear W21350169622015 @default.
• W2135016962 countsByYear W21350169622016 @default.
• W2135016962 countsByYear W21350169622017 @default.
• W2135016962 countsByYear W21350169622018 @default.
• W2135016962 countsByYear W21350169622019 @default.
• W2135016962 countsByYear W21350169622020 @default.
• W2135016962 countsByYear W21350169622021 @default.
• W2135016962 countsByYear W21350169622022 @default.
• W2135016962 countsByYear W21350169622023 @default.
• W2135016962 crossrefType "journal-article" @default.
• W2135016962 hasAuthorship W2135016962A5030470781 @default.
• W2135016962 hasAuthorship W2135016962A5037501365 @default.
• W2135016962 hasAuthorship W2135016962A5042304008 @default.
• W2135016962 hasAuthorship W2135016962A5054548078 @default.
• W2135016962 hasAuthorship W2135016962A5067852918 @default.
• W2135016962 hasAuthorship W2135016962A5070330260 @default.
• W2135016962 hasAuthorship W2135016962A5076276224 @default.
• W2135016962 hasBestOaLocation W21350169622 @default.
• W2135016962 hasConcept C104317684 @default.
• W2135016962 hasConcept C126322002 @default.
• W2135016962 hasConcept C160448771 @default.
• W2135016962 hasConcept C174832134 @default.
• W2135016962 hasConcept C2777700362 @default.
• W2135016962 hasConcept C2777785397 @default.
• W2135016962 hasConcept C2780678043 @default.
• W2135016962 hasConcept C54355233 @default.
• W2135016962 hasConcept C60987743 @default.

• next