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- W2135016992 abstract "Arsenic toxicokinetics are important for disease risks in exposed populations, but genetic determinants are not fully understood. We examined urine arsenic species patterns measured by HPLC-ICPMS among 2189 Strong Heart Study participants 18 years of age and older with data on ~400 genome-wide microsatellite markers spaced ~10 cM and arsenic speciation (683 participants from Arizona, 684 from Oklahoma, and 822 from North and South Dakota). We logit-transformed % arsenic species (% inorganic arsenic, %MMA, and %DMA) and also conducted principal component analyses of the logit % arsenic species. We used inverse-normalized residuals from multivariable-adjusted polygenic heritability analysis for multipoint variance components linkage analysis. We also examined the contribution of polymorphisms in the arsenic metabolism gene AS3MT via conditional linkage analysis. We localized a quantitative trait locus (QTL) on chromosome 10 (LOD 4.12 for %MMA, 4.65 for %DMA, and 4.84 for the first principal component of logit % arsenic species). This peak was partially but not fully explained by measured AS3MT variants. We also localized a QTL for the second principal component of logit % arsenic species on chromosome 5 (LOD 4.21) that was not evident from considering % arsenic species individually. Some other loci were suggestive or significant for 1 geographical area but not overall across all areas, indicating possible locus heterogeneity. This genome-wide linkage scan suggests genetic determinants of arsenic toxicokinetics to be identified by future fine-mapping, and illustrates the utility of principal component analysis as a novel approach that considers % arsenic species jointly." @default.
- W2135016992 created "2016-06-24" @default.
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- W2135016992 date "2015-07-23" @default.
- W2135016992 modified "2023-10-17" @default.
- W2135016992 title "Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study" @default.
- W2135016992 cites W1550259003 @default.
- W2135016992 cites W1955438083 @default.
- W2135016992 cites W1963548002 @default.
- W2135016992 cites W1967999651 @default.
- W2135016992 cites W1972943167 @default.
- W2135016992 cites W1974187478 @default.
- W2135016992 cites W1974497758 @default.
- W2135016992 cites W1976741643 @default.
- W2135016992 cites W1977089938 @default.
- W2135016992 cites W1982180050 @default.
- W2135016992 cites W1985417765 @default.
- W2135016992 cites W1988046859 @default.
- W2135016992 cites W1993799589 @default.
- W2135016992 cites W1994889966 @default.
- W2135016992 cites W1996506894 @default.
- W2135016992 cites W2001126413 @default.
- W2135016992 cites W2001310740 @default.
- W2135016992 cites W2003021146 @default.
- W2135016992 cites W2003021208 @default.
- W2135016992 cites W2006859372 @default.
- W2135016992 cites W2006945601 @default.
- W2135016992 cites W2009103131 @default.
- W2135016992 cites W2009305435 @default.
- W2135016992 cites W2016902028 @default.
- W2135016992 cites W2018475333 @default.
- W2135016992 cites W2023176508 @default.
- W2135016992 cites W2024885145 @default.
- W2135016992 cites W2030701454 @default.
- W2135016992 cites W2031296193 @default.
- W2135016992 cites W2032736587 @default.
- W2135016992 cites W2034014190 @default.
- W2135016992 cites W2035581319 @default.
- W2135016992 cites W2036990611 @default.
- W2135016992 cites W2038076288 @default.
- W2135016992 cites W2041746316 @default.
- W2135016992 cites W2044394153 @default.
- W2135016992 cites W2045943926 @default.
- W2135016992 cites W2046155936 @default.
- W2135016992 cites W2046471358 @default.
- W2135016992 cites W2046903314 @default.
- W2135016992 cites W2047372557 @default.
- W2135016992 cites W2052477316 @default.
- W2135016992 cites W2058900411 @default.
- W2135016992 cites W2059230629 @default.
- W2135016992 cites W2062013876 @default.
- W2135016992 cites W2063125403 @default.
- W2135016992 cites W2063474035 @default.
- W2135016992 cites W2063492468 @default.
- W2135016992 cites W2067947422 @default.
- W2135016992 cites W2068807890 @default.
- W2135016992 cites W2075426814 @default.
- W2135016992 cites W2080430831 @default.
- W2135016992 cites W2083983543 @default.
- W2135016992 cites W2084472395 @default.
- W2135016992 cites W2088546840 @default.
- W2135016992 cites W2088806699 @default.
- W2135016992 cites W2089747160 @default.
- W2135016992 cites W2090933558 @default.
- W2135016992 cites W2101163981 @default.
- W2135016992 cites W2104854465 @default.
- W2135016992 cites W2106380683 @default.
- W2135016992 cites W2106830850 @default.
- W2135016992 cites W2115232714 @default.
- W2135016992 cites W2115335486 @default.
- W2135016992 cites W2116977954 @default.
- W2135016992 cites W2117534189 @default.
- W2135016992 cites W2120030040 @default.
- W2135016992 cites W2121754812 @default.
- W2135016992 cites W2122302405 @default.
- W2135016992 cites W2124353746 @default.
- W2135016992 cites W2125922899 @default.
- W2135016992 cites W2128865876 @default.
- W2135016992 cites W2129089132 @default.
- W2135016992 cites W2133451549 @default.
- W2135016992 cites W2133702107 @default.
- W2135016992 cites W2133911145 @default.
- W2135016992 cites W2136142349 @default.
- W2135016992 cites W2137821173 @default.