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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135020532> ?p ?o ?g. }

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• W2135020532 startingPage "1061" @default.
• W2135020532 abstract "Integrin-linked kinase (ILK) is a serine/threonine kinase that interacts with the cytoplasmic domain of β-integrins and growth factor receptors in response to extracellular signals. It is a key molecule in cell adhesion, proliferation, and cell survival. We found that treating cells with specific inhibitors of the heat shock protein 90 (Hsp90) caused rapid cell detachment. Screening the responsible proteins revealed a decreased amount of ILK in Hsp90 inhibitor-treated cells. ILK was identified as a new Hsp90 client protein because it formed a complex with Hsp90 and Cdc37, and binding was suppressed by Hsp90 inhibitors. Experiments with a series of ILK-deletion mutants revealed that the amino acid residues 377–406 were required for Hsp90 binding. Dissociation of ILK from Hsp90 shortened its half-life by promoting proteasome-dependent degradation. These results indicate that Hsp90 plays an important role in the stability of ILK in cells." @default.
• W2135020532 created "2016-06-24" @default.
• W2135020532 creator A5000523070 @default.
• W2135020532 creator A5033231895 @default.
• W2135020532 creator A5081291585 @default.
• W2135020532 date "2005-06-01" @default.
• W2135020532 modified "2023-10-13" @default.
• W2135020532 title "Stabilization of integrin-linked kinase by binding to Hsp90" @default.
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• W2135020532 doi "https://doi.org/10.1016/j.bbrc.2005.03.225" @default.
• W2135020532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15882985" @default.
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