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- W2135032017 endingPage "1302" @default.
- W2135032017 startingPage "1291" @default.
- W2135032017 abstract "All fundamental reproductive events in the human ovary and uterus, including ovulation, implantation and menstruation, are dependent upon profound tissue remodelling, characterized by cyclical waves of cell proliferation, differentiation, recruitment of inflammatory cells, apoptosis, tissue breakdown and regeneration. Although the rise and fall in ovarian hormones, estradiol and progesterone, orchestrate these reproductive events, FOXO transcription factors, an evolutionary conserved subfamily of forkhead transcription factors, have emerged major downstream effector molecules, capable of integrating hormonal cues with a variety of stress, growth factor and cytokine signal transduction pathways. The ability of FOXOs to regulate seemingly opposing cellular responses, ranging from cell cycle arrest and oxidative stress responses to differentiation and apoptosis, renders these transcription factors indispensable for cyclic tissue remodelling in the reproductive tract. Aberrant expression or perturbed activity of FOXO transcription factors are increasingly linked to prevalent reproductive disorders, such as endometriosis, endometrial cancer, primary ovarian insufficiency and pregnancy failure, which in turn highlights their potential as therapeutic targets." @default.
- W2135032017 created "2016-06-24" @default.
- W2135032017 creator A5025845183 @default.
- W2135032017 creator A5036102592 @default.
- W2135032017 creator A5046724888 @default.
- W2135032017 creator A5079166449 @default.
- W2135032017 date "2011-08-01" @default.
- W2135032017 modified "2023-09-30" @default.
- W2135032017 title "FOXO Transcription Factors and their Role in Disorders of the Female Reproductive Tract" @default.
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