FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135038818> ?p ?o ?g. }

• W2135038818 endingPage "3012" @default.
• W2135038818 startingPage "3000" @default.
• W2135038818 abstract "Abstract Genome scans of population differentiation identify candidate loci for adaptation but provide little information on how selection has influenced the genetic structure of these loci. Following a genome scan, we investigated the nature of the selection responsible for the outlying differentiation observed between populations of the marine mussel Mytilus edulis at a leucine/arginine polymorphism ( L31R ) in the antimicrobial peptide MGD 2. We analysed DNA sequence polymorphisms, allele frequencies and population differentiation of polymorphisms closely linked to L31R , and pairwise and third‐order linkage disequilibria. An outlying level of population differentiation was observed at L31R only, while no departure from panmixia was observed at linked loci surrounding L31R , as in most of the genome. Selection therefore seems to affect L31R directly. Three hypotheses can explain the lack of differentiation in the chromosomal region close to L31R : (i) hitchhiking has occurred but migration and recombination subsequently erased the signal, (ii) selection was weak enough and recombination strong enough to limit the hitchhiking effect to a very small chromosomal region or (iii) selection acted on a pre‐existing polymorphism (i.e. standing variation) at linkage equilibrium with its background. Linkage equilibrium was observed between L31R and linked polymorphisms in every population analysed, as expected under the three hypotheses. However, linkage disequilibrium was observed in some populations between pairs of loci located upstream and downstream to L31R , generating a complex pattern of third‐order linkage disequilibria which is best explained by the hypothesis of selection on a pre‐existing polymorphism. We hypothesise that selection could be either balanced, maintaining alleles at different frequencies depending on the pathogen community encountered locally by mussels, or intermittent, resulting in sporadic fluctuations in allele frequency." @default.
• W2135038818 created "2016-06-24" @default.
• W2135038818 creator A5009564501 @default.
• W2135038818 creator A5009597030 @default.
• W2135038818 creator A5030374119 @default.
• W2135038818 creator A5057275312 @default.
• W2135038818 date "2014-06-01" @default.
• W2135038818 modified "2023-10-17" @default.
• W2135038818 title "Evidence for adaptation from standing genetic variation on an antimicrobial peptide gene in the mussel<i>Mytilus edulis</i>" @default.
• W2135038818 cites W1503215610 @default.
• W2135038818 cites W1517803630 @default.
• W2135038818 cites W1530461011 @default.
• W2135038818 cites W1562018117 @default.
• W2135038818 cites W1570272209 @default.
• W2135038818 cites W1596652233 @default.
• W2135038818 cites W1827525950 @default.
• W2135038818 cites W1870614750 @default.
• W2135038818 cites W1908810753 @default.
• W2135038818 cites W1915195716 @default.
• W2135038818 cites W1932538605 @default.
• W2135038818 cites W1971728472 @default.
• W2135038818 cites W1973298000 @default.
• W2135038818 cites W1974301483 @default.
• W2135038818 cites W1976122633 @default.
• W2135038818 cites W1976844960 @default.
• W2135038818 cites W1979553217 @default.
• W2135038818 cites W1980980457 @default.
• W2135038818 cites W1983151212 @default.
• W2135038818 cites W1988383178 @default.
• W2135038818 cites W1998197559 @default.
• W2135038818 cites W2005222110 @default.
• W2135038818 cites W2006688902 @default.
• W2135038818 cites W2020943359 @default.
• W2135038818 cites W2021736445 @default.
• W2135038818 cites W2031991994 @default.
• W2135038818 cites W2036507199 @default.
• W2135038818 cites W2047417387 @default.
• W2135038818 cites W2050340111 @default.
• W2135038818 cites W2052270758 @default.
• W2135038818 cites W2054602599 @default.
• W2135038818 cites W2055298722 @default.
• W2135038818 cites W2060435573 @default.
• W2135038818 cites W2062935524 @default.
• W2135038818 cites W2063697565 @default.
• W2135038818 cites W2063809692 @default.
• W2135038818 cites W2064947972 @default.
• W2135038818 cites W2068851900 @default.
• W2135038818 cites W2081664487 @default.
• W2135038818 cites W2082967637 @default.
• W2135038818 cites W2100152398 @default.
• W2135038818 cites W2101733503 @default.
• W2135038818 cites W2106882534 @default.
• W2135038818 cites W2112799266 @default.
• W2135038818 cites W2113035052 @default.
• W2135038818 cites W2113258368 @default.
• W2135038818 cites W2115783150 @default.
• W2135038818 cites W2116652744 @default.
• W2135038818 cites W2118055782 @default.
• W2135038818 cites W2119652557 @default.
• W2135038818 cites W2121504310 @default.
• W2135038818 cites W2123002474 @default.
• W2135038818 cites W2123157959 @default.
• W2135038818 cites W2123575603 @default.
• W2135038818 cites W2127075690 @default.
• W2135038818 cites W2135496660 @default.
• W2135038818 cites W2137303277 @default.
• W2135038818 cites W2142464651 @default.
• W2135038818 cites W2143557413 @default.
• W2135038818 cites W2146337296 @default.
• W2135038818 cites W2149575932 @default.
• W2135038818 cites W2151061572 @default.
• W2135038818 cites W2153118443 @default.
• W2135038818 cites W2155408399 @default.
• W2135038818 cites W2155745416 @default.
• W2135038818 cites W2156643192 @default.
• W2135038818 cites W2156866331 @default.
• W2135038818 cites W2157149092 @default.
• W2135038818 cites W2160805016 @default.
• W2135038818 cites W2162157671 @default.
• W2135038818 cites W2162884431 @default.
• W2135038818 cites W2167852412 @default.
• W2135038818 cites W2168488178 @default.
• W2135038818 cites W2168560149 @default.
• W2135038818 cites W2169421412 @default.
• W2135038818 cites W4253414868 @default.
• W2135038818 doi "https://doi.org/10.1111/mec.12784" @default.
• W2135038818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24805928" @default.
• W2135038818 hasPublicationYear "2014" @default.
• W2135038818 type Work @default.
• W2135038818 sameAs 2135038818 @default.
• W2135038818 citedByCount "20" @default.
• W2135038818 countsByYear W21350388182015 @default.
• W2135038818 countsByYear W21350388182016 @default.
• W2135038818 countsByYear W21350388182017 @default.
• W2135038818 countsByYear W21350388182018 @default.
• W2135038818 countsByYear W21350388182019 @default.
• W2135038818 countsByYear W21350388182020 @default.
• W2135038818 countsByYear W21350388182021 @default.

• next