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• W2135044265 endingPage "14746" @default.
• W2135044265 startingPage "14741" @default.
• W2135044265 abstract "In plants, silencing of mRNA can be transmitted from cell to cell and also over longer distances from roots to shoots. To investigate the long-distance mechanism, WT and mutant shoots were grafted onto roots silenced for an mRNA. We show that three genes involved in a chromatin silencing pathway, NRPD1a encoding RNA polymerase IVa, RNA-dependent RNA polymerase 2 ( RDR2 ), and DICER-like 3 ( DCL3 ), are required for reception of long-distance mRNA silencing in the shoot. A mutant representing a fourth gene in the pathway, argonaute4 ( ago4 ), was also partially compromised in the reception of silencing. This pathway produces 24-nt siRNAs and resulted in decapped RNA, a known substrate for amplification of dsRNA by RDR6. Activation of silencing in grafted shoots depended on RDR6, but no 24-nt siRNAs were detected in mutant rdr6 shoots, indicating that RDR6 also plays a role in initial signal perception. After amplification of decapped transcripts, DCL4 and DCL2 act hierarchically as they do in antiviral resistance to produce 21- and 22-nt siRNAs, respectively, and these guide mRNA degradation. Several dcl genotypes were also tested for their capacity to transmit the mobile silencing signal from the rootstock. dcl1–8 and a dcl2 dcl3 dcl4 triple mutant are compromised in micro-RNA and siRNA biogenesis, respectively, but were unaffected in signal transmission." @default.
• W2135044265 created "2016-06-24" @default.
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• W2135044265 date "2007-09-11" @default.
• W2135044265 modified "2023-09-27" @default.
• W2135044265 title "Nuclear gene silencing directs reception of long-distance mRNA silencing in <i>Arabidopsis</i>" @default.
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• W2135044265 doi "https://doi.org/10.1073/pnas.0706701104" @default.
• W2135044265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1964546" @default.
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• W2135044265 hasPublicationYear "2007" @default.
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