Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135050220> ?p ?o ?g. }
- W2135050220 endingPage "e194" @default.
- W2135050220 startingPage "e194" @default.
- W2135050220 abstract "High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values." @default.
- W2135050220 created "2016-06-24" @default.
- W2135050220 creator A5003774733 @default.
- W2135050220 creator A5004204696 @default.
- W2135050220 creator A5008075208 @default.
- W2135050220 creator A5012619895 @default.
- W2135050220 creator A5013097813 @default.
- W2135050220 creator A5014263171 @default.
- W2135050220 creator A5014880234 @default.
- W2135050220 creator A5018612024 @default.
- W2135050220 creator A5024004432 @default.
- W2135050220 creator A5033840995 @default.
- W2135050220 creator A5034327821 @default.
- W2135050220 creator A5035724824 @default.
- W2135050220 creator A5043426193 @default.
- W2135050220 creator A5045118261 @default.
- W2135050220 creator A5048196698 @default.
- W2135050220 creator A5060742163 @default.
- W2135050220 creator A5072213487 @default.
- W2135050220 creator A5077291181 @default.
- W2135050220 creator A5079340049 @default.
- W2135050220 creator A5081270721 @default.
- W2135050220 creator A5083273309 @default.
- W2135050220 creator A5085568887 @default.
- W2135050220 creator A5087049187 @default.
- W2135050220 creator A5091741059 @default.
- W2135050220 date "2007-11-09" @default.
- W2135050220 modified "2023-10-17" @default.
- W2135050220 title "The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts" @default.
- W2135050220 cites W1948619662 @default.
- W2135050220 cites W1985305462 @default.
- W2135050220 cites W1997915675 @default.
- W2135050220 cites W2010730354 @default.
- W2135050220 cites W2022192230 @default.
- W2135050220 cites W2023572457 @default.
- W2135050220 cites W2024718317 @default.
- W2135050220 cites W2025372788 @default.
- W2135050220 cites W2034293014 @default.
- W2135050220 cites W2077448009 @default.
- W2135050220 cites W2106362601 @default.
- W2135050220 cites W2108280526 @default.
- W2135050220 cites W2113528337 @default.
- W2135050220 cites W2117842210 @default.
- W2135050220 cites W2128016314 @default.
- W2135050220 cites W2144911879 @default.
- W2135050220 cites W2149786401 @default.
- W2135050220 cites W2168675093 @default.
- W2135050220 cites W2217809488 @default.
- W2135050220 cites W2323300482 @default.
- W2135050220 cites W2329022484 @default.
- W2135050220 doi "https://doi.org/10.1371/journal.pgen.0030194" @default.
- W2135050220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2065883" @default.
- W2135050220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17997608" @default.
- W2135050220 hasPublicationYear "2007" @default.
- W2135050220 type Work @default.
- W2135050220 sameAs 2135050220 @default.
- W2135050220 citedByCount "264" @default.
- W2135050220 countsByYear W21350502202012 @default.
- W2135050220 countsByYear W21350502202013 @default.
- W2135050220 countsByYear W21350502202014 @default.
- W2135050220 countsByYear W21350502202015 @default.
- W2135050220 countsByYear W21350502202016 @default.
- W2135050220 countsByYear W21350502202017 @default.
- W2135050220 countsByYear W21350502202018 @default.
- W2135050220 countsByYear W21350502202019 @default.
- W2135050220 countsByYear W21350502202020 @default.
- W2135050220 countsByYear W21350502202021 @default.
- W2135050220 countsByYear W21350502202022 @default.
- W2135050220 countsByYear W21350502202023 @default.
- W2135050220 crossrefType "journal-article" @default.
- W2135050220 hasAuthorship W2135050220A5003774733 @default.
- W2135050220 hasAuthorship W2135050220A5004204696 @default.
- W2135050220 hasAuthorship W2135050220A5008075208 @default.
- W2135050220 hasAuthorship W2135050220A5012619895 @default.
- W2135050220 hasAuthorship W2135050220A5013097813 @default.
- W2135050220 hasAuthorship W2135050220A5014263171 @default.
- W2135050220 hasAuthorship W2135050220A5014880234 @default.
- W2135050220 hasAuthorship W2135050220A5018612024 @default.
- W2135050220 hasAuthorship W2135050220A5024004432 @default.
- W2135050220 hasAuthorship W2135050220A5033840995 @default.
- W2135050220 hasAuthorship W2135050220A5034327821 @default.
- W2135050220 hasAuthorship W2135050220A5035724824 @default.
- W2135050220 hasAuthorship W2135050220A5043426193 @default.
- W2135050220 hasAuthorship W2135050220A5045118261 @default.
- W2135050220 hasAuthorship W2135050220A5048196698 @default.
- W2135050220 hasAuthorship W2135050220A5060742163 @default.
- W2135050220 hasAuthorship W2135050220A5072213487 @default.
- W2135050220 hasAuthorship W2135050220A5077291181 @default.
- W2135050220 hasAuthorship W2135050220A5079340049 @default.
- W2135050220 hasAuthorship W2135050220A5081270721 @default.
- W2135050220 hasAuthorship W2135050220A5083273309 @default.
- W2135050220 hasAuthorship W2135050220A5085568887 @default.
- W2135050220 hasAuthorship W2135050220A5087049187 @default.
- W2135050220 hasAuthorship W2135050220A5091741059 @default.
- W2135050220 hasBestOaLocation W21350502201 @default.
- W2135050220 hasConcept C104317684 @default.
- W2135050220 hasConcept C126322002 @default.
- W2135050220 hasConcept C134018914 @default.