FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135051330> ?p ?o ?g. }

• W2135051330 endingPage "R1052" @default.
• W2135051330 startingPage "R1044" @default.
• W2135051330 abstract "Polyunsaturated fatty acids (PUFAs) can have strong effects on hibernation and daily torpor in mammals. High dietary PUFA contents were found to increase proneness for torpor, decrease body temperatures, prolong torpor bout duration, and attenuate hibernation mass loss. The mechanism by which PUFAs enhance torpor and hibernation is unknown, however. On the basis of a review of the literature, and on reexamining our own data on alpine marmots, we propose that effects on hibernation are not due to PUFAs in general, but to shifts in the ratio of n-6 PUFAs to n-3 PUFAs in membrane phospholipids. Specifically, high ratios of n-6 to n-3 PUFAs increase the activity of the Ca 2+ -Mg 2+ pump in the sarcoplasmic reticulum of the heart (SERCA) and counteract Q 10 effects on SERCA activity at low tissue temperatures. Therefore, high n-6 to n-3 PUFA ratios in cardiac myocyte membranes appear to protect the hibernating heart from arrhythmia, which in hypothermic nonhibernators is caused by massive increases in cytosolic Ca 2+ . The resulting reduced risk of cardiac arrest during hypothermia may explain why increased dietary uptake of n-6 PUFAs, but not of n-3 PUFAs, can strongly enhance the propensity for hibernation, and allows heterotherms to reach lower body temperatures, with associated increased energy savings. Therefore, at least for herbivorous hibernators, such as marmots, linoleic acid (C18:2 n-6)—the dietary source of all n-6 PUFAs—appears to represent a crucial and limited resource in natural environments." @default.
• W2135051330 created "2016-06-24" @default.
• W2135051330 creator A5051100676 @default.
• W2135051330 creator A5087294179 @default.
• W2135051330 date "2008-03-01" @default.
• W2135051330 modified "2023-10-16" @default.
• W2135051330 title "Effects of polyunsaturated fatty acids on hibernation and torpor: a review and hypothesis" @default.
• W2135051330 cites W1574714516 @default.
• W2135051330 cites W1774726957 @default.
• W2135051330 cites W1809648194 @default.
• W2135051330 cites W1854722798 @default.
• W2135051330 cites W1969469260 @default.
• W2135051330 cites W1970660006 @default.
• W2135051330 cites W1970877762 @default.
• W2135051330 cites W1973175580 @default.
• W2135051330 cites W1977035804 @default.
• W2135051330 cites W1980125322 @default.
• W2135051330 cites W1982248012 @default.
• W2135051330 cites W1986225307 @default.
• W2135051330 cites W1993012254 @default.
• W2135051330 cites W1994759225 @default.
• W2135051330 cites W1994897146 @default.
• W2135051330 cites W1996795941 @default.
• W2135051330 cites W1999134458 @default.
• W2135051330 cites W1999232937 @default.
• W2135051330 cites W1999444082 @default.
• W2135051330 cites W2002924161 @default.
• W2135051330 cites W2003201206 @default.
• W2135051330 cites W2004313693 @default.
• W2135051330 cites W2006243101 @default.
• W2135051330 cites W2007223858 @default.
• W2135051330 cites W2013578935 @default.
• W2135051330 cites W2021178815 @default.
• W2135051330 cites W2030428209 @default.
• W2135051330 cites W2033329829 @default.
• W2135051330 cites W2034629044 @default.
• W2135051330 cites W2038063878 @default.
• W2135051330 cites W2041308924 @default.
• W2135051330 cites W2041313434 @default.
• W2135051330 cites W2047239547 @default.
• W2135051330 cites W2048535876 @default.
• W2135051330 cites W2049547343 @default.
• W2135051330 cites W2050057935 @default.
• W2135051330 cites W2050824263 @default.
• W2135051330 cites W2056614353 @default.
• W2135051330 cites W2057241898 @default.
• W2135051330 cites W2057522312 @default.
• W2135051330 cites W2062690720 @default.
• W2135051330 cites W2066445331 @default.
• W2135051330 cites W2069372169 @default.
• W2135051330 cites W2071194994 @default.
• W2135051330 cites W2071668260 @default.
• W2135051330 cites W2080080000 @default.
• W2135051330 cites W2085467491 @default.
• W2135051330 cites W2090053637 @default.
• W2135051330 cites W2090506996 @default.
• W2135051330 cites W2091973116 @default.
• W2135051330 cites W2094975748 @default.
• W2135051330 cites W2124035137 @default.
• W2135051330 cites W2126246154 @default.
• W2135051330 cites W2134147742 @default.
• W2135051330 cites W2135041233 @default.
• W2135051330 cites W2137001845 @default.
• W2135051330 cites W2138639799 @default.
• W2135051330 cites W2138904934 @default.
• W2135051330 cites W2139097751 @default.
• W2135051330 cites W2140614773 @default.
• W2135051330 cites W2141905943 @default.
• W2135051330 cites W2145960092 @default.
• W2135051330 cites W2157495637 @default.
• W2135051330 cites W2164624443 @default.
• W2135051330 cites W2168495918 @default.
• W2135051330 cites W2199311655 @default.
• W2135051330 cites W2223245791 @default.
• W2135051330 cites W2232194921 @default.
• W2135051330 cites W2280727155 @default.
• W2135051330 cites W2283889781 @default.
• W2135051330 cites W2285223957 @default.
• W2135051330 cites W2322728051 @default.
• W2135051330 cites W2333641169 @default.
• W2135051330 cites W2338643284 @default.
• W2135051330 cites W2407364126 @default.
• W2135051330 cites W2954364899 @default.
• W2135051330 doi "https://doi.org/10.1152/ajpregu.00688.2007" @default.
• W2135051330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18171691" @default.
• W2135051330 hasPublicationYear "2008" @default.
• W2135051330 type Work @default.
• W2135051330 sameAs 2135051330 @default.
• W2135051330 citedByCount "120" @default.
• W2135051330 countsByYear W21350513302012 @default.
• W2135051330 countsByYear W21350513302013 @default.
• W2135051330 countsByYear W21350513302014 @default.
• W2135051330 countsByYear W21350513302015 @default.
• W2135051330 countsByYear W21350513302016 @default.
• W2135051330 countsByYear W21350513302017 @default.
• W2135051330 countsByYear W21350513302018 @default.
• W2135051330 countsByYear W21350513302019 @default.
• W2135051330 countsByYear W21350513302020 @default.

• next