FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135058419> ?p ?o ?g. }

• W2135058419 endingPage "840" @default.
• W2135058419 startingPage "832" @default.
• W2135058419 abstract "Aim: Chymase converts angiotensin I to angiotensin II, which may promote the development of liver fibrosis. In this study, whether a chymase inhibitor TY-51469 attenuated tetrachloride (CCl4)-induced liver fibrosis was examined. Methods: Liver fibrosis was induced by the s.c. injection of 1 mL/kg of CCl4 twice weekly for 8 weeks, and each hamster was given TY-51469 (1 mg/kg per day) or placebo. Untreated hamsters were used as a control group. Results: Significant increases of serum alanine aminotransferase, total bilirubin and hyaluronic acid levels were observed in the placebo-treated group compared with the control group, but these levels were significantly attenuated in the TY-51469-treated group. Liver chymase activity was significantly higher in the placebo-treated group than in the control group, whereas the activity in the TY51469-treated group was not. Total angiotensin II-forming activity in the liver was also significantly higher in the placebo-treatedgroup than in the control group or the TY-51469-treated group. The ratio of the fibrotic area to the total area in the liver was significantly higher in the placebo-treated group than in the control group, but the ratio was significantly lower in the TY-51469-treated group than in the placebo-treated group. A significant decrease in the number of α-smooth muscle actin (SMA)-positive cells was seen in the TY-51469-treated group compared to the placebo-treated group. Conclusion: Significant correlations between the number of chymase-positive cells and the degree of fibrosis and between the numbers of chymase-positive cells and α-SMA-positive cells were observed. Thus, chymase inhibition may be a useful strategy for preventing liver fibrosis." @default.
• W2135058419 created "2016-06-24" @default.
• W2135058419 creator A5005522744 @default.
• W2135058419 creator A5006420479 @default.
• W2135058419 creator A5028138186 @default.
• W2135058419 creator A5037231478 @default.
• W2135058419 creator A5054542665 @default.
• W2135058419 creator A5054579480 @default.
• W2135058419 creator A5064112047 @default.
• W2135058419 date "2010-07-07" @default.
• W2135058419 modified "2023-10-17" @default.
• W2135058419 title "Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters" @default.
• W2135058419 cites W1964030529 @default.
• W2135058419 cites W1967059750 @default.
• W2135058419 cites W1972576054 @default.
• W2135058419 cites W1984261234 @default.
• W2135058419 cites W1988282390 @default.
• W2135058419 cites W1991212627 @default.
• W2135058419 cites W1992676488 @default.
• W2135058419 cites W1994733930 @default.
• W2135058419 cites W2000515235 @default.
• W2135058419 cites W2002491528 @default.
• W2135058419 cites W2008643088 @default.
• W2135058419 cites W2010138952 @default.
• W2135058419 cites W2016601455 @default.
• W2135058419 cites W2025743530 @default.
• W2135058419 cites W2037902035 @default.
• W2135058419 cites W2059307783 @default.
• W2135058419 cites W2071660979 @default.
• W2135058419 cites W2075056638 @default.
• W2135058419 cites W2086833378 @default.
• W2135058419 cites W2093379100 @default.
• W2135058419 cites W2111525805 @default.
• W2135058419 cites W2119230542 @default.
• W2135058419 cites W2124053963 @default.
• W2135058419 cites W2126910515 @default.
• W2135058419 cites W2134974760 @default.
• W2135058419 cites W2149072614 @default.
• W2135058419 cites W2150472477 @default.
• W2135058419 cites W2157630219 @default.
• W2135058419 cites W2166360182 @default.
• W2135058419 cites W2172073611 @default.
• W2135058419 cites W2335187016 @default.
• W2135058419 doi "https://doi.org/10.1111/j.1872-034x.2010.00672.x" @default.
• W2135058419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20626468" @default.
• W2135058419 hasPublicationYear "2010" @default.
• W2135058419 type Work @default.
• W2135058419 sameAs 2135058419 @default.
• W2135058419 citedByCount "24" @default.
• W2135058419 countsByYear W21350584192012 @default.
• W2135058419 countsByYear W21350584192013 @default.
• W2135058419 countsByYear W21350584192014 @default.
• W2135058419 countsByYear W21350584192016 @default.
• W2135058419 countsByYear W21350584192017 @default.
• W2135058419 countsByYear W21350584192018 @default.
• W2135058419 countsByYear W21350584192019 @default.
• W2135058419 countsByYear W21350584192020 @default.
• W2135058419 countsByYear W21350584192021 @default.
• W2135058419 countsByYear W21350584192022 @default.
• W2135058419 countsByYear W21350584192023 @default.
• W2135058419 crossrefType "journal-article" @default.
• W2135058419 hasAuthorship W2135058419A5005522744 @default.
• W2135058419 hasAuthorship W2135058419A5006420479 @default.
• W2135058419 hasAuthorship W2135058419A5028138186 @default.
• W2135058419 hasAuthorship W2135058419A5037231478 @default.
• W2135058419 hasAuthorship W2135058419A5054542665 @default.
• W2135058419 hasAuthorship W2135058419A5054579480 @default.
• W2135058419 hasAuthorship W2135058419A5064112047 @default.
• W2135058419 hasConcept C126322002 @default.
• W2135058419 hasConcept C134018914 @default.
• W2135058419 hasConcept C142724271 @default.
• W2135058419 hasConcept C178790620 @default.
• W2135058419 hasConcept C185592680 @default.
• W2135058419 hasConcept C203014093 @default.
• W2135058419 hasConcept C204787440 @default.
• W2135058419 hasConcept C27081682 @default.
• W2135058419 hasConcept C2777359374 @default.
• W2135058419 hasConcept C2778575167 @default.
• W2135058419 hasConcept C2779726688 @default.
• W2135058419 hasConcept C2780559512 @default.
• W2135058419 hasConcept C2780614898 @default.
• W2135058419 hasConcept C2908929049 @default.
• W2135058419 hasConcept C71924100 @default.
• W2135058419 hasConcept C84393581 @default.
• W2135058419 hasConcept C90924648 @default.
• W2135058419 hasConceptScore W2135058419C126322002 @default.
• W2135058419 hasConceptScore W2135058419C134018914 @default.
• W2135058419 hasConceptScore W2135058419C142724271 @default.
• W2135058419 hasConceptScore W2135058419C178790620 @default.
• W2135058419 hasConceptScore W2135058419C185592680 @default.
• W2135058419 hasConceptScore W2135058419C203014093 @default.
• W2135058419 hasConceptScore W2135058419C204787440 @default.
• W2135058419 hasConceptScore W2135058419C27081682 @default.
• W2135058419 hasConceptScore W2135058419C2777359374 @default.
• W2135058419 hasConceptScore W2135058419C2778575167 @default.
• W2135058419 hasConceptScore W2135058419C2779726688 @default.
• W2135058419 hasConceptScore W2135058419C2780559512 @default.
• W2135058419 hasConceptScore W2135058419C2780614898 @default.

• next