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• W2135065215 abstract "Diabetes has been associated to the risk of a few cancer sites, though quantification of this association in various populations remains open to discussion. We analyzed the relation between diabetes and the risk of various cancers in an integrated series of case-control studies conducted in Italy and Switzerland between 1991 and 2009. The studies included 1,468 oral and pharyngeal, 505 esophageal, 230 gastric, 2,390 colorectal, 185 liver, 326 pancreatic, 852 laryngeal, 3,034 breast, 607 endometrial, 1,031 ovarian, 1,294 prostate, and 767 renal cell cancer cases and 12,060 hospital controls. The multivariate odds ratios (OR) for subjects with diabetes as compared to those without—adjusted for major identified confounding factors for the cancers considered through logistic regression models—were significantly elevated for cancers of the oral cavity/pharynx (OR = 1.58), esophagus (OR = 2.52), colorectum (OR = 1.23), liver (OR = 3.52), pancreas (OR = 3.32), postmenopausal breast (OR = 1.76), and endometrium (OR = 1.70). For cancers of the oral cavity, esophagus, colorectum, liver, and postmenopausal breast, the excess risk persisted over 10 yr since diagnosis of diabetes. Our data confirm and further quantify the association of diabetes with colorectal, liver, pancreatic, postmenopausal breast, and endometrial cancer and suggest forthe first time that diabetes may also increase the risk of oral/pharyngeal and esophageal cancer. Diabetes Mellitus and Cancer Risk in a Network of Case-Control StudiesAll authorsCristina Bosetti, Valentina Rosato, Jerry Polesel, Fabio Levi, Renato Talamini, Maurizio Montella, Eva Negri, Alessandra Tavani, Antonella Zucchetto, Silvia Franceschi, Giovanni Corrao & Carlo La Vecchiahttps://doi.org/10.1080/01635581.2012.676141Published online:02 July 2012 TABLE 1 Number of cases of selected cancer sites and controls and corresponding median age in Italy and Switzerland, 1991–2009 Download CSVDisplay Table Diabetes Mellitus and Cancer Risk in a Network of Case-Control StudiesAll authorsCristina Bosetti, Valentina Rosato, Jerry Polesel, Fabio Levi, Renato Talamini, Maurizio Montella, Eva Negri, Alessandra Tavani, Antonella Zucchetto, Silvia Franceschi, Giovanni Corrao & Carlo La Vecchiahttps://doi.org/10.1080/01635581.2012.676141Published online:02 July 2012 TABLE 2 Distribution of cases of selected cancer sites and corresponding controls, and odds ratios (OR) and 95% confidence intervals (CI) according to history of diabetes in Italy and Switzerland, 1991–2009 Download CSVDisplay Table" @default.
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• W2135065215 date "2012-07-01" @default.
• W2135065215 modified "2023-10-18" @default.
• W2135065215 title "Diabetes Mellitus and Cancer Risk in a Network of Case-Control Studies" @default.
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