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• W2135072010 abstract "BackgroundT-1249 is a 39–amino acid synthetic peptide fusion inhibitor (FI) shown to preserve antiretroviral activity in vitro against human immunodeficiency virus (HIV) isolates that have decreased susceptibility to enfuvirtide (ENF) MethodsA 10-day phase 1/2 study of the safety and antiretroviral activity of T-1249 was conducted in 53 HIV-1–infected adults with detectable viremia while on an ENF-containing treatment regimen ResultsFrom FI-naive baseline levels, the geometric mean (GM) decrease in susceptibility to ENF was 116.3-fold, and the GM decrease in susceptibility to T-1249 was 2.0-fold. Patients continued to administer their failing treatment regimen but replaced ENF with T-1249 at a dose of 192 mg/day. T-1249 was generally well tolerated; injection site reactions, which were generally mild, were the most commonly reported adverse event (64% of patients). The median change from levels of HIV-1 RNA at baseline to levels on day 11 was −1.26 log10 copies/mL (95% confidence interval, −1.40 to −1.09 log10 copies/mL); on day 11, a decrease from baseline HIV-1 RNA levels of ⩾1.0 log10 copies/mL was seen in 73% of patients. Antiretroviral activity, as measured by levels of HIV-1 RNA, was not predicted by baseline susceptibility to T-1249 or to ENF; genotypic substitutions that emerged during T-1249 treatment were identified in virus from some patients ConclusionsThese results indicate that FIs constitute an expanding class of antiretroviral agents with the potential to be sequenced" @default.
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• W2135072010 date "2005-04-01" @default.
• W2135072010 modified "2023-09-24" @default.
• W2135072010 title "T‐1249 Retains Potent Antiretroviral Activity in Patients Who Had Experienced Virological Failure while on an Enfuvirtide‐Containing Treatment Regimen" @default.
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• W2135072010 doi "https://doi.org/10.1086/427993" @default.
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