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• W2135079655 abstract "Enrollment in interventional therapeutic clinical trials is a small fraction of all patients who might participate given reasonable access.A hierarchical approach is utilized in measuring staged participation from trial availability to patient enrollment. Our framework suggests that concern for justice comes in the design and eligibility criteria for clinical trials; attention to beneficence is given in the eligibility and physician triage stages. The remaining four stages rely on respect for persons. An example is given where reasons for nonparticipation or barriers to participation in prostate cancer clinical trials are examined within the framework. In addition, medical oncology patients with an initial six month consultation are tracked from one stage to the next by race using the framework to assess participation comparability.We illustrated seven transitions from being a patient to enrollment in a clinical trial in a small study of prostate cancer cases who consulted SKCCC Medical Oncology Department in early 2010. Pilot data suggest transition probabilities as follows: 65% availability, 84% eligibility, 92% patient triage, 89% trials discussed, 45% patient interested, 63% patient consented, and 92% patient enrolled. The average transition probability was 77.7%. The average transition probability, patient-trial-fit was 50%; opportunity was 51%, and acceptance was 66.7%. Trial availability, patient interest and patient consented were three transitions that were below the average; none were statistically significant.The framework may serve to streamline comprehensive reporting of clinical trial participation to the benefit of patients and the ethical conduct of clinical trials." @default.
• W2135079655 created "2016-06-24" @default.
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• W2135079655 date "2012-12-01" @default.
• W2135079655 modified "2023-09-26" @default.
• W2135079655 title "Removing barriers to participation in clinical trials, a conceptual framework and retrospective chart review study" @default.
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• W2135079655 doi "https://doi.org/10.1186/1745-6215-13-237" @default.
• W2135079655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3551829" @default.
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