FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135087145> ?p ?o ?g. }

• W2135087145 endingPage "1144" @default.
• W2135087145 startingPage "1137" @default.
• W2135087145 abstract "ATP has recently emerged as an important proinflammatory mediator that has direct excitatory actions on sensory neurons through activation of ion channel-coupled P2X receptors. The purpose of the current work is to assess whether ATP alters the release of neuropeptides from sensory neurons and the receptors mediating this putative action. Exposing embryonic sensory neurons in culture to concentrations of ATP up to 300 μm did not increase the release of immunoreactive substance P or calcitonin gene-related peptide from sensory neurons. However, pre-exposing sensory neurons to 0.1 to100 μm ATP prior to and throughout administration of 30 nM capsaicin resulted in a significant augmentation of release evoked by the vanilloid. This sensitizing action of ATP is blocked by suramin but not pyridoxal phosphate-6-azobenzene-2,4-disulfonic acid and is mimicked by the P2Y receptor agonists, 2-2-chloroadenosine triphosphate and UTP, but not by 2-(methylthio)adenosine 5′-triphosphate or α,β-methyleneadenosine 5′-diphosphate. This profile of drug actions suggests that the sensitizing actions of ATP are mediated by P2Y receptors. Pretreating sensory neurons with bisindolylmaleimide I, a selective protein kinase C (PKC) inhibitor, attenuates the augmentation of capsaicin-induced peptide release by ATP, further implicating P2Y receptors in the actions of ATP. Immunoblotting also indicates the presence of P2Y₂-like immunoreactive substance in embryonic dorsal root ganglia neurons. Together, these data support the notion that ATP acts at P2Y receptors in sensory neurons in a PKC-dependent manner to augment their sensitivity to other stimuli." @default.
• W2135087145 created "2016-06-24" @default.
• W2135087145 creator A5004776917 @default.
• W2135087145 creator A5008169135 @default.
• W2135087145 creator A5037701654 @default.
• W2135087145 creator A5038763745 @default.
• W2135087145 creator A5085209847 @default.
• W2135087145 date "2003-06-26" @default.
• W2135087145 modified "2023-10-12" @default.
• W2135087145 title "ATP Augments Peptide Release from Rat Sensory Neurons in Culture through Activation of P2Y Receptors" @default.
• W2135087145 cites W1492591187 @default.
• W2135087145 cites W1623121663 @default.
• W2135087145 cites W1675050582 @default.
• W2135087145 cites W1862246641 @default.
• W2135087145 cites W1985030046 @default.
• W2135087145 cites W1988231418 @default.
• W2135087145 cites W2013609823 @default.
• W2135087145 cites W2014683303 @default.
• W2135087145 cites W2025313004 @default.
• W2135087145 cites W2025672036 @default.
• W2135087145 cites W2029100084 @default.
• W2135087145 cites W2039457863 @default.
• W2135087145 cites W2048201868 @default.
• W2135087145 cites W2049100687 @default.
• W2135087145 cites W2049261807 @default.
• W2135087145 cites W2052750950 @default.
• W2135087145 cites W2056882527 @default.
• W2135087145 cites W2083457444 @default.
• W2135087145 cites W2084701217 @default.
• W2135087145 cites W2085789947 @default.
• W2135087145 cites W2090813510 @default.
• W2135087145 cites W2091190709 @default.
• W2135087145 cites W2091207754 @default.
• W2135087145 cites W2091539852 @default.
• W2135087145 cites W2091991131 @default.
• W2135087145 cites W2140327830 @default.
• W2135087145 cites W2145192310 @default.
• W2135087145 cites W2160876060 @default.
• W2135087145 doi "https://doi.org/10.1124/jpet.103.052951" @default.
• W2135087145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12829729" @default.
• W2135087145 hasPublicationYear "2003" @default.
• W2135087145 type Work @default.
• W2135087145 sameAs 2135087145 @default.
• W2135087145 citedByCount "36" @default.
• W2135087145 countsByYear W21350871452012 @default.
• W2135087145 countsByYear W21350871452013 @default.
• W2135087145 countsByYear W21350871452014 @default.
• W2135087145 countsByYear W21350871452015 @default.
• W2135087145 crossrefType "journal-article" @default.
• W2135087145 hasAuthorship W2135087145A5004776917 @default.
• W2135087145 hasAuthorship W2135087145A5008169135 @default.
• W2135087145 hasAuthorship W2135087145A5037701654 @default.
• W2135087145 hasAuthorship W2135087145A5038763745 @default.
• W2135087145 hasAuthorship W2135087145A5085209847 @default.
• W2135087145 hasConcept C104317684 @default.
• W2135087145 hasConcept C118303440 @default.
• W2135087145 hasConcept C160225129 @default.
• W2135087145 hasConcept C170493617 @default.
• W2135087145 hasConcept C185592680 @default.
• W2135087145 hasConcept C2775908076 @default.
• W2135087145 hasConcept C2776182878 @default.
• W2135087145 hasConcept C2776533618 @default.
• W2135087145 hasConcept C2778564976 @default.
• W2135087145 hasConcept C2779564974 @default.
• W2135087145 hasConcept C2780019924 @default.
• W2135087145 hasConcept C2780410667 @default.
• W2135087145 hasConcept C512185932 @default.
• W2135087145 hasConcept C55493867 @default.
• W2135087145 hasConcept C57306754 @default.
• W2135087145 hasConcept C86803240 @default.
• W2135087145 hasConcept C95444343 @default.
• W2135087145 hasConceptScore W2135087145C104317684 @default.
• W2135087145 hasConceptScore W2135087145C118303440 @default.
• W2135087145 hasConceptScore W2135087145C160225129 @default.
• W2135087145 hasConceptScore W2135087145C170493617 @default.
• W2135087145 hasConceptScore W2135087145C185592680 @default.
• W2135087145 hasConceptScore W2135087145C2775908076 @default.
• W2135087145 hasConceptScore W2135087145C2776182878 @default.
• W2135087145 hasConceptScore W2135087145C2776533618 @default.
• W2135087145 hasConceptScore W2135087145C2778564976 @default.
• W2135087145 hasConceptScore W2135087145C2779564974 @default.
• W2135087145 hasConceptScore W2135087145C2780019924 @default.
• W2135087145 hasConceptScore W2135087145C2780410667 @default.
• W2135087145 hasConceptScore W2135087145C512185932 @default.
• W2135087145 hasConceptScore W2135087145C55493867 @default.
• W2135087145 hasConceptScore W2135087145C57306754 @default.
• W2135087145 hasConceptScore W2135087145C86803240 @default.
• W2135087145 hasConceptScore W2135087145C95444343 @default.
• W2135087145 hasIssue "3" @default.
• W2135087145 hasLocation W21350871451 @default.
• W2135087145 hasLocation W21350871452 @default.
• W2135087145 hasOpenAccess W2135087145 @default.
• W2135087145 hasPrimaryLocation W21350871451 @default.
• W2135087145 hasRelatedWork W2003698595 @default.
• W2135087145 hasRelatedWork W2020880088 @default.
• W2135087145 hasRelatedWork W2039308583 @default.
• W2135087145 hasRelatedWork W2039644412 @default.
• W2135087145 hasRelatedWork W2052690399 @default.

• next