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- W2135102498 endingPage "1015" @default.
- W2135102498 startingPage "997" @default.
- W2135102498 abstract "Abstract The yeast pheromone/filamentous growth MAPK pathway mediates both mating and invasive-growth responses. The interface between this MAPK module and the transcriptional machinery consists of a network of two MAPKs, Fus3 and Kss1; two regulators, Rst1 and Rst2 (a.k.a. Dig1 and Dig2); and two transcription factors, Ste12 and Tec1. Of 16 possible combinations of gene deletions in FUS3, KSS1, RST1, and RST2 in the Σ1278 background, 10 display constitutive invasive growth. Rst1 was the primary negative regulator of invasive growth, while other components either attenuated or enhanced invasive growth, depending on the genetic context. Despite activation of the invasive response by lesions at the same level in the MAPK pathway, transcriptional profiles of different invasive mutant combinations did not exhibit a unified program of gene expression. The distal MAPK regulatory network is thus capable of generating phenotypically similar invasive-growth states (an attractor) from different molecular architectures (trajectories) that can functionally compensate for one another. This systems-level robustness may also account for the observed diversity of signals that trigger invasive growth." @default.
- W2135102498 created "2016-06-24" @default.
- W2135102498 creator A5028073379 @default.
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- W2135102498 creator A5057700057 @default.
- W2135102498 creator A5061843783 @default.
- W2135102498 creator A5062216764 @default.
- W2135102498 date "2003-11-01" @default.
- W2135102498 modified "2023-10-14" @default.
- W2135102498 title "Phenotypic and Transcriptional Plasticity Directed by a Yeast Mitogen-Activated Protein Kinase Network" @default.
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- W2135102498 doi "https://doi.org/10.1093/genetics/165.3.997" @default.