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- W2135106119 abstract "1-(3-Chlorophenyl)-3-diethylcarbamoyl-1 H-1,2,4-triazole (CP-32,961) inhibited [3H]diazepam binding to rat cortical membrances and [3H]flunitrazepam binding to mouse brain in vivo. Its inhibition of the binding of [3H]Ro 15-1788 (benzodiazepine receptor antagonist) to these membranes was not facilitated by added GABA; CP-32,961 exhibited a GABA ratio of 0.84 compared to 2.44 for diazepam. Cerebellar cyclic GMP content in rats was raised by CP-32,961, which also further elevated the increased cyclic GMP levels induced by isoniazid. These neurochemical actions are similar to those shown by ethyl β-carboline-3-carboxylate (β-CCE) and suggest that CP-32,961 is a benzodiazepine receptor antagonist with inverse agonist activity." @default.
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- W2135106119 date "1985-01-01" @default.
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- W2135106119 title "Biochemical evidence for a new benzodiazepine receptor antagonist" @default.
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- W2135106119 doi "https://doi.org/10.1002/ddr.430060410" @default.
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