FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135114425> ?p ?o ?g. }

• W2135114425 endingPage "1772" @default.
• W2135114425 startingPage "1764" @default.
• W2135114425 abstract "Only a fraction of cigarette smokers develop lung cancer, suggesting that people differ in their susceptibility to this disease. We investigated whether differences in DNA repair capacity (DRC) for repairing tobacco carcinogen-induced DNA damage are associated with differential susceptibility to lung cancer.From August 1, 1995, through April 30, 1999, we conducted a hospital-based, case-control study of 316 newly diagnosed lung cancer patients and 316 cancer-free control subjects matched on age, sex, and smoking status. DRC was measured in cultured lymphocytes with the use of the host-cell reactivation assay with a reporter gene damaged by a known activated tobacco carcinogen, benzo[a]pyrene diol epoxide. Statistical tests were two-sided.Overall, lower DRC was observed in case patients than in control subjects (P:<.001) and was associated with a greater than twofold increased risk of lung cancer. Compared with the highest DRC quartile in the control subjects and after adjustment for age, sex, pack-years of smoking, family history of cancer, and other covariates, reduced DRC was associated with increased risk of lung cancer in a dose-dependent fashion (odds ratio [OR] = 1.8 with 95% confidence interval [CI] = 1.1-3.1, OR = 2.0 with 95% CI = 1.2-3.4, and OR = 4. 3 with 95% CI = 2.6-7.2 for the second, third, and fourth quartiles, respectively; P:(trend)<.001). Case patients who were younger at diagnosis (<60 years old), female, or lighter smokers or who reported a family history of cancer exhibited the lowest DRC and the highest lung cancer risk among their subgroups, suggesting that these subgroups may be especially susceptible to lung cancer.The results provide evidence that low DRC is associated with increased risk of lung cancer. The findings from this hospital-based, case-control study should be validated in prospective studies." @default.
• W2135114425 created "2016-06-24" @default.
• W2135114425 creator A5012002845 @default.
• W2135114425 creator A5028989565 @default.
• W2135114425 creator A5035156015 @default.
• W2135114425 creator A5057886462 @default.
• W2135114425 creator A5060545230 @default.
• W2135114425 creator A5070791449 @default.
• W2135114425 creator A5085188591 @default.
• W2135114425 date "2000-11-01" @default.
• W2135114425 modified "2023-10-17" @default.
• W2135114425 title "Repair of Tobacco Carcinogen-Induced DNA Adducts and Lung Cancer Risk: a Molecular Epidemiologic Study" @default.
• W2135114425 cites W1518470897 @default.
• W2135114425 cites W1557669107 @default.
• W2135114425 cites W1588636403 @default.
• W2135114425 cites W1604381017 @default.
• W2135114425 cites W1770653080 @default.
• W2135114425 cites W1817423755 @default.
• W2135114425 cites W181871780 @default.
• W2135114425 cites W1831692175 @default.
• W2135114425 cites W1881840670 @default.
• W2135114425 cites W1906080430 @default.
• W2135114425 cites W1967221425 @default.
• W2135114425 cites W1969432521 @default.
• W2135114425 cites W1970294374 @default.
• W2135114425 cites W1970555747 @default.
• W2135114425 cites W1976056213 @default.
• W2135114425 cites W1977522788 @default.
• W2135114425 cites W1979343286 @default.
• W2135114425 cites W1981008066 @default.
• W2135114425 cites W1984825020 @default.
• W2135114425 cites W1986672886 @default.
• W2135114425 cites W1989980834 @default.
• W2135114425 cites W1999163677 @default.
• W2135114425 cites W2018448933 @default.
• W2135114425 cites W2020818957 @default.
• W2135114425 cites W2022187136 @default.
• W2135114425 cites W2024581740 @default.
• W2135114425 cites W2026671700 @default.
• W2135114425 cites W2027632514 @default.
• W2135114425 cites W2032907468 @default.
• W2135114425 cites W2033410478 @default.
• W2135114425 cites W2035326394 @default.
• W2135114425 cites W2036523030 @default.
• W2135114425 cites W2038399829 @default.
• W2135114425 cites W2042316019 @default.
• W2135114425 cites W2058703907 @default.
• W2135114425 cites W2062197102 @default.
• W2135114425 cites W2064818248 @default.
• W2135114425 cites W2077060586 @default.
• W2135114425 cites W2100867813 @default.
• W2135114425 cites W2102232287 @default.
• W2135114425 cites W2102550332 @default.
• W2135114425 cites W2146474005 @default.
• W2135114425 cites W2153443383 @default.
• W2135114425 cites W2155375778 @default.
• W2135114425 cites W2163864783 @default.
• W2135114425 cites W2179627804 @default.
• W2135114425 cites W2185879258 @default.
• W2135114425 cites W2252688746 @default.
• W2135114425 cites W2268869167 @default.
• W2135114425 cites W2281366036 @default.
• W2135114425 cites W2292552118 @default.
• W2135114425 cites W2329646608 @default.
• W2135114425 cites W82306716 @default.
• W2135114425 doi "https://doi.org/10.1093/jnci/92.21.1764" @default.
• W2135114425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11058619" @default.
• W2135114425 hasPublicationYear "2000" @default.
• W2135114425 type Work @default.
• W2135114425 sameAs 2135114425 @default.
• W2135114425 citedByCount "439" @default.
• W2135114425 countsByYear W21351144252012 @default.
• W2135114425 countsByYear W21351144252013 @default.
• W2135114425 countsByYear W21351144252014 @default.
• W2135114425 countsByYear W21351144252015 @default.
• W2135114425 countsByYear W21351144252016 @default.
• W2135114425 countsByYear W21351144252017 @default.
• W2135114425 countsByYear W21351144252018 @default.
• W2135114425 countsByYear W21351144252019 @default.
• W2135114425 countsByYear W21351144252020 @default.
• W2135114425 countsByYear W21351144252021 @default.
• W2135114425 countsByYear W21351144252022 @default.
• W2135114425 countsByYear W21351144252023 @default.
• W2135114425 crossrefType "journal-article" @default.
• W2135114425 hasAuthorship W2135114425A5012002845 @default.
• W2135114425 hasAuthorship W2135114425A5028989565 @default.
• W2135114425 hasAuthorship W2135114425A5035156015 @default.
• W2135114425 hasAuthorship W2135114425A5057886462 @default.
• W2135114425 hasAuthorship W2135114425A5060545230 @default.
• W2135114425 hasAuthorship W2135114425A5070791449 @default.
• W2135114425 hasAuthorship W2135114425A5085188591 @default.
• W2135114425 hasBestOaLocation W21351144251 @default.
• W2135114425 hasConcept C114246631 @default.
• W2135114425 hasConcept C121608353 @default.
• W2135114425 hasConcept C126322002 @default.
• W2135114425 hasConcept C143998085 @default.
• W2135114425 hasConcept C146304588 @default.
• W2135114425 hasConcept C156957248 @default.

• next