Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135121448> ?p ?o ?g. }
- W2135121448 endingPage "3265" @default.
- W2135121448 startingPage "3253" @default.
- W2135121448 abstract "The presence of brown adipose tissue (BAT) in human adults opens attractive perspectives to treat metabolic disorders. Indeed, BAT dissipates energy as heat via uncoupling protein (UCP)1. Brown adipocytes are located in specific deposits or can emerge among white fat through the so-called browning process. Although numerous inducers have been shown to drive this process, no study has investigated whether it could be controlled by specific metabolites. Here, we show that lactate, an important metabolic intermediate, induces browning of murine white adipose cells with expression of functional UCP1. Lactate-induced browning also occurs in human cells and in vivo. Lactate controls Ucp1 expression independently of hypoxia-inducible factor-1α and PPARα pathways but requires active PPARγ signaling. We demonstrate that the lactate effect on Ucp1 is mediated by intracellular redox modifications as a result of lactate transport through monocarboxylate transporters. Further, the ketone body β-hydroxybutyrate, another metabolite that impacts redox state, is also a strong browning inducer. Because this redox-dependent increase in Ucp1 expression promotes an oxidative phenotype with mitochondria, browning appears as an adaptive mechanism to alleviate redox pressure. Our findings open new perspectives for the control of adipose tissue browning and its physiological relevance." @default.
- W2135121448 created "2016-06-24" @default.
- W2135121448 creator A5003437583 @default.
- W2135121448 creator A5006573265 @default.
- W2135121448 creator A5016834843 @default.
- W2135121448 creator A5020666068 @default.
- W2135121448 creator A5034272596 @default.
- W2135121448 creator A5035641825 @default.
- W2135121448 creator A5036600652 @default.
- W2135121448 creator A5048137628 @default.
- W2135121448 creator A5050327823 @default.
- W2135121448 creator A5052469937 @default.
- W2135121448 creator A5052885964 @default.
- W2135121448 creator A5054126539 @default.
- W2135121448 creator A5072506531 @default.
- W2135121448 creator A5082840988 @default.
- W2135121448 creator A5084915485 @default.
- W2135121448 creator A5085708867 @default.
- W2135121448 creator A5091807308 @default.
- W2135121448 date "2014-09-15" @default.
- W2135121448 modified "2023-10-16" @default.
- W2135121448 title "Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure" @default.
- W2135121448 cites W1616394907 @default.
- W2135121448 cites W1662558499 @default.
- W2135121448 cites W1862333831 @default.
- W2135121448 cites W1900866157 @default.
- W2135121448 cites W1963377486 @default.
- W2135121448 cites W1974418613 @default.
- W2135121448 cites W1979026577 @default.
- W2135121448 cites W1982089533 @default.
- W2135121448 cites W2003842905 @default.
- W2135121448 cites W2004009973 @default.
- W2135121448 cites W2005827500 @default.
- W2135121448 cites W2007129300 @default.
- W2135121448 cites W2007772114 @default.
- W2135121448 cites W2012538520 @default.
- W2135121448 cites W2027786827 @default.
- W2135121448 cites W2035963507 @default.
- W2135121448 cites W2041068624 @default.
- W2135121448 cites W2046550445 @default.
- W2135121448 cites W2051243229 @default.
- W2135121448 cites W2054987125 @default.
- W2135121448 cites W2062420270 @default.
- W2135121448 cites W2077239351 @default.
- W2135121448 cites W2079482653 @default.
- W2135121448 cites W2079933309 @default.
- W2135121448 cites W2084377042 @default.
- W2135121448 cites W2085397620 @default.
- W2135121448 cites W2088441277 @default.
- W2135121448 cites W2092379975 @default.
- W2135121448 cites W2099810479 @default.
- W2135121448 cites W2111365962 @default.
- W2135121448 cites W2112578326 @default.
- W2135121448 cites W2112936536 @default.
- W2135121448 cites W2118055379 @default.
- W2135121448 cites W2124857894 @default.
- W2135121448 cites W2132053398 @default.
- W2135121448 cites W2132358997 @default.
- W2135121448 cites W2132968158 @default.
- W2135121448 cites W2135341087 @default.
- W2135121448 cites W2148548585 @default.
- W2135121448 cites W2153942347 @default.
- W2135121448 cites W2155184914 @default.
- W2135121448 cites W2155957566 @default.
- W2135121448 cites W2162023168 @default.
- W2135121448 cites W2163468424 @default.
- W2135121448 cites W2163785511 @default.
- W2135121448 cites W2170874580 @default.
- W2135121448 cites W53784274 @default.
- W2135121448 doi "https://doi.org/10.2337/db13-1885" @default.
- W2135121448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24789919" @default.
- W2135121448 hasPublicationYear "2014" @default.
- W2135121448 type Work @default.
- W2135121448 sameAs 2135121448 @default.
- W2135121448 citedByCount "205" @default.
- W2135121448 countsByYear W21351214482014 @default.
- W2135121448 countsByYear W21351214482015 @default.
- W2135121448 countsByYear W21351214482016 @default.
- W2135121448 countsByYear W21351214482017 @default.
- W2135121448 countsByYear W21351214482018 @default.
- W2135121448 countsByYear W21351214482019 @default.
- W2135121448 countsByYear W21351214482020 @default.
- W2135121448 countsByYear W21351214482021 @default.
- W2135121448 countsByYear W21351214482022 @default.
- W2135121448 countsByYear W21351214482023 @default.
- W2135121448 crossrefType "journal-article" @default.
- W2135121448 hasAuthorship W2135121448A5003437583 @default.
- W2135121448 hasAuthorship W2135121448A5006573265 @default.
- W2135121448 hasAuthorship W2135121448A5016834843 @default.
- W2135121448 hasAuthorship W2135121448A5020666068 @default.
- W2135121448 hasAuthorship W2135121448A5034272596 @default.
- W2135121448 hasAuthorship W2135121448A5035641825 @default.
- W2135121448 hasAuthorship W2135121448A5036600652 @default.
- W2135121448 hasAuthorship W2135121448A5048137628 @default.
- W2135121448 hasAuthorship W2135121448A5050327823 @default.
- W2135121448 hasAuthorship W2135121448A5052469937 @default.
- W2135121448 hasAuthorship W2135121448A5052885964 @default.
- W2135121448 hasAuthorship W2135121448A5054126539 @default.