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• W2135124612 abstract "Background There is only retrospective evidence for the efficacy of narrowband ultraviolet B (NB-UVB) in children with eczema. Objectives To measure the difference in means for objective scores [Six Area Six Sign Atopic Dermatitis score (SASSAD), percentage surface area] and quality-of-life scores, between patients treated with NB-UVB and unexposed cohorts at the end of treatment, and 3 and 6 months post-treatment. Methods Twenty-nine children aged 3–16 years for whom NB-UVB was indicated, were scored prospectively using SASSAD and percentage surface area involvement at baseline, at 12 weeks (end of treatment) and 3 and 6 months post-NB-UVB. Their scores were compared with those of unexposed children (n = 26) for whom NB-UVB phototherapy was indicated and offered, but who chose not to undertake treatment. Results There was a 61% reduction in mean SASSAD score in the NB-UVB cohort compared with an increase of 6% in the unexposed cohort. Mean SASSAD score for the NB-UVB cohort at the end of treatment was 11·6 vs. 24·8 for the unexposed; difference in means −13·2 [95% confidence interval (CI) −18·7 to −7·7, P < 0·0001]. Mean surface area involvement at the end of treatment was 11% for the NB-UVB cohort vs. 36% for the unexposed cohort; difference in means −25% (95% CI −34% to −16%, P < 0·0001). Subjective and quality-of-life scores showed significant difference between cohorts at the end of treatment (P < 0·05). Objective scores remained significantly lower than in the unexposed cohort 3 and 6 months after treatment. Conclusion NB-UVB is clinically effective and improves quality of life in children with moderate-to-severe eczema. The effect is maintained for 6 months after treatment." @default.
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• W2135124612 date "2014-01-01" @default.
• W2135124612 modified "2023-10-16" @default.
• W2135124612 title "Narrowband ultraviolet B phototherapy in children with moderate-to-severe eczema: a comparative cohort study" @default.
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• W2135124612 doi "https://doi.org/10.1111/bjd.12580" @default.
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