FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135164162> ?p ?o ?g. }

• W2135164162 endingPage "108" @default.
• W2135164162 startingPage "93" @default.
• W2135164162 abstract "The success of coronary artery bypass graft surgery (CABG) depends mainly on the patency of the graft vessels. Aortocoronary vein graft disease is comprised of three distinct but interrelated pathological processes: thrombosis, intimal hyperplasia and atherosclerosis. Early thrombosis is a major cause of vein graft attrition during the first month after CABG, while during the remainder of the first year, intimal hyperplasia forms a template for subsequent atherogenesis, which thereafter predominates. Platelets play a crucial role in the pathophysiology of graft thrombosis and aspirin is the primary antiplatelet drug that has been shown to improve vein graft patency within the first year after CABG. Nevertheless, a significant number of grafts still occlude in the early postoperative period despite ‘appropriate’ aspirin treatment. Moreover, laboratory investigations showed that the expected inhibition of platelet function is not always achieved. This has been called ‘aspirin nonresponse’ or ‘aspirin resistance’, although a uniform definition is lacking. The finding that a considerable number of patients show an impaired antiplatelet effect of aspirin after CABG brought new insight into the discussion concerning poor patency rates of bypass grafts: the early period after CABG shows a coincidence of an increased risk for bypass thrombosis (amongst others, due to platelet activation and endothelial cell disruption of the graft) and an increased prevalence of aspirin resistance. Hitherto, the underlying mechanisms of aspirin resistance are uncertain and largely hypothetical; amongst others, increased platelet turnover, enhanced platelet reactivity, systemic inflammation, and drug–drug interaction are discussed. Up to now available data concerning the clinical outcome of aspirin resistant CABG patients are limited, and there is evidence that platelets of patients with graft thrombosis are more likely to be resistant to aspirin compared with patients without thrombotic events. Many publications concerning aspirin resistance are available today, but reports addressing this topic in CABG patients are sparse. This review summarises recent insights into the antiplatelet treatment after CABG and describes the clinical benefit, but also the therapeutic failure of the well-established drug aspirin. Moreover, possible pharmacological approaches to improve antithrombotic therapy in aspirin nonresponders among CABG patients are discussed." @default.
• W2135164162 created "2016-06-24" @default.
• W2135164162 creator A5019007539 @default.
• W2135164162 creator A5058662198 @default.
• W2135164162 creator A5081822906 @default.
• W2135164162 date "2008-07-01" @default.
• W2135164162 modified "2023-10-13" @default.
• W2135164162 title "Aspirin in coronary artery bypass surgery: new aspects of and alternatives for an old antithrombotic agent" @default.
• W2135164162 cites W1501120985 @default.
• W2135164162 cites W1532880878 @default.
• W2135164162 cites W1553345686 @default.
• W2135164162 cites W1568334797 @default.
• W2135164162 cites W1966544868 @default.
• W2135164162 cites W1968460690 @default.
• W2135164162 cites W1971952644 @default.
• W2135164162 cites W1974048860 @default.
• W2135164162 cites W1981260144 @default.
• W2135164162 cites W1981500593 @default.
• W2135164162 cites W1983822972 @default.
• W2135164162 cites W1986299008 @default.
• W2135164162 cites W1988143463 @default.
• W2135164162 cites W1990149423 @default.
• W2135164162 cites W1990799972 @default.
• W2135164162 cites W1997343401 @default.
• W2135164162 cites W1999715184 @default.
• W2135164162 cites W2000607508 @default.
• W2135164162 cites W2002294861 @default.
• W2135164162 cites W2002636327 @default.
• W2135164162 cites W2006861054 @default.
• W2135164162 cites W2007627203 @default.
• W2135164162 cites W2007745737 @default.
• W2135164162 cites W2008574207 @default.
• W2135164162 cites W2011327495 @default.
• W2135164162 cites W2011861566 @default.
• W2135164162 cites W2011941025 @default.
• W2135164162 cites W2015311559 @default.
• W2135164162 cites W2015521606 @default.
• W2135164162 cites W2019432529 @default.
• W2135164162 cites W2019477930 @default.
• W2135164162 cites W2020686426 @default.
• W2135164162 cites W2024352468 @default.
• W2135164162 cites W2026785948 @default.
• W2135164162 cites W2029707641 @default.
• W2135164162 cites W2030789648 @default.
• W2135164162 cites W2030977683 @default.
• W2135164162 cites W2031517152 @default.
• W2135164162 cites W2034368138 @default.
• W2135164162 cites W2040093075 @default.
• W2135164162 cites W2044774138 @default.
• W2135164162 cites W2045046768 @default.
• W2135164162 cites W2049122691 @default.
• W2135164162 cites W2053379248 @default.
• W2135164162 cites W2057048935 @default.
• W2135164162 cites W2057645565 @default.
• W2135164162 cites W2058168108 @default.
• W2135164162 cites W2065879102 @default.
• W2135164162 cites W2065893762 @default.
• W2135164162 cites W2066072643 @default.
• W2135164162 cites W2069475893 @default.
• W2135164162 cites W2070321224 @default.
• W2135164162 cites W2070892802 @default.
• W2135164162 cites W2071650970 @default.
• W2135164162 cites W2075981472 @default.
• W2135164162 cites W2079964926 @default.
• W2135164162 cites W2080471069 @default.
• W2135164162 cites W2082254603 @default.
• W2135164162 cites W2082901685 @default.
• W2135164162 cites W2085447892 @default.
• W2135164162 cites W2090890063 @default.
• W2135164162 cites W2094306425 @default.
• W2135164162 cites W2095834825 @default.
• W2135164162 cites W2100209149 @default.
• W2135164162 cites W2103301522 @default.
• W2135164162 cites W2104595603 @default.
• W2135164162 cites W2109973294 @default.
• W2135164162 cites W2113248132 @default.
• W2135164162 cites W2115041325 @default.
• W2135164162 cites W2120027412 @default.
• W2135164162 cites W2122485640 @default.
• W2135164162 cites W2125389594 @default.
• W2135164162 cites W2126919236 @default.
• W2135164162 cites W2133358158 @default.
• W2135164162 cites W2135491318 @default.
• W2135164162 cites W2135581684 @default.
• W2135164162 cites W2135780868 @default.
• W2135164162 cites W2138121477 @default.
• W2135164162 cites W2140482107 @default.
• W2135164162 cites W2149863735 @default.
• W2135164162 cites W2156266070 @default.
• W2135164162 cites W2156278436 @default.
• W2135164162 cites W2158123405 @default.
• W2135164162 cites W2158960911 @default.
• W2135164162 cites W2158986029 @default.
• W2135164162 cites W2160085333 @default.
• W2135164162 cites W2160256608 @default.
• W2135164162 cites W2161043271 @default.
• W2135164162 cites W2167067204 @default.
• W2135164162 cites W2168978330 @default.

• next