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- W2135183762 abstract "Cell models for prion diseases are mainly of neuronal origin. However, the pathological isoform PrPSc of cellular prion protein (PrPc) and prion infectivity are found in a variety of extraneural tissues in prion diseases. Although many cell types are not able to propagate PrPSc, little is known about cellular mechanism counteracting prion infection. It is desirable to identify neuronal or non-neuronal cell models that restrict PrPSc generation or propagate PrPSc only transiently. Neuroendocrine cells are derived from tumours forming the interface between endocrine and nervous system. We investigated the susceptibility of such murine cell lines to prion infection, which were in principle able to transiently propagate PrPSc. Surprisingly and in contrast to neuronal cells prion infection was abrogated by rapid and PrPSc-specific down-regulation of PrPc expression upon exposure to prion-infected material. Cell lines described here provide novel models for studying PrPc regulation and intrinsic cellular defence mechanisms upon prion exposure." @default.
- W2135183762 created "2016-06-24" @default.
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- W2135183762 date "2008-05-01" @default.
- W2135183762 modified "2023-09-23" @default.
- W2135183762 title "Neuroendocrine cultured cells counteract persistent prion infection by down-regulation of PrPc" @default.
- W2135183762 cites W1514133366 @default.
- W2135183762 cites W1514782173 @default.
- W2135183762 cites W1533604120 @default.
- W2135183762 cites W1543396712 @default.
- W2135183762 cites W1562048972 @default.
- W2135183762 cites W1563004998 @default.
- W2135183762 cites W1590689549 @default.
- W2135183762 cites W1827691446 @default.
- W2135183762 cites W1966535643 @default.
- W2135183762 cites W1970987171 @default.
- W2135183762 cites W1974595102 @default.
- W2135183762 cites W1979678617 @default.
- W2135183762 cites W1981738652 @default.
- W2135183762 cites W1982040954 @default.
- W2135183762 cites W1983750916 @default.
- W2135183762 cites W1984171856 @default.
- W2135183762 cites W1985384585 @default.
- W2135183762 cites W1990627959 @default.
- W2135183762 cites W1991211881 @default.
- W2135183762 cites W1996648035 @default.
- W2135183762 cites W1997259637 @default.
- W2135183762 cites W2000999460 @default.
- W2135183762 cites W2007093034 @default.
- W2135183762 cites W2012405730 @default.
- W2135183762 cites W2018631295 @default.
- W2135183762 cites W2019007228 @default.
- W2135183762 cites W2029428782 @default.
- W2135183762 cites W2037491812 @default.
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- W2135183762 cites W2043923768 @default.
- W2135183762 cites W2044937144 @default.
- W2135183762 cites W2053069642 @default.
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- W2135183762 cites W2088456311 @default.
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- W2135183762 doi "https://doi.org/10.1016/j.mcn.2008.02.004" @default.
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