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• W2135184362 abstract "Significance Although early studies suggested that cannabinoid CB 2 receptors (CB 2 Rs) are absent in the brain, this view has been challenged by recent findings of significant brain CB 2 R involvement in several dopamine (DA)-related CNS disorders. The cellular mechanisms underlying these actions are unclear, however. Using multiple approaches, we found that CB 2 R genes and receptors are expressed in midbrain DA neurons, and that activation of CB 2 Rs inhibits DA neuronal firing and i.v. cocaine self-administration. These findings not only challenge the long-held view that brain CB 2 Rs are not expressed in neurons, but also suggest that neuronal CB 2 Rs modulate DA neuronal activity and DA-regulated behavior. Thus, brain CB 2 Rs may constitute a new therapeutic target in medication development for treatment of a number of CNS disorders." @default.
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• W2135184362 date "2014-11-03" @default.
• W2135184362 modified "2023-10-12" @default.
• W2135184362 title "Cannabinoid CB ₂ receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice" @default.
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• W2135184362 doi "https://doi.org/10.1073/pnas.1413210111" @default.
• W2135184362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4246322" @default.
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