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- W2135187729 abstract "Background: The various components of pain and quality of life in duodenal ulcer patients receiving antisecretory drugs have not been studied to date. Methods: Ninety-five patients with epigastric pain and duodenal ulcer at endoscopy completed this prospective, multicenter, open-study. All were treated with effervescent ranitidine 300 mg daily for 4 weeks. The following parameters were assessed: (a) disappearance of duodenal ulcer pain by self-evaluation and on a weekly visual analogue scale (VAS) from 0 to 100; (b) evolution of sensory and affective components of ulcer pain by the Validated French Version of the McGill Pain Questionnaire (Questionnaire Douleur de Saint-Antoine, QDSA); (c) quality of life by the Nottingham Health Profile (NHP) which includes six criteria: pain, mobility, energy, emotions, sleep and social isolation. Results: Forty-nine, 66 and 87% of the patients were pain-free during the day-time after 7, 14 and 28 days, respectively. Corresponding figures for the night-time were 80%, 88% and 97% respectively. Median time to disappearance of ulcer pain was 8 days. VAS self-assessment showed a significant decrease each week throughout the treatment period (P= 0.001). Sensory and affective QDSA scores were significantly improved after the second day and at each assessment during the 28 days of treatment (P= 0.001). Physical as well as affective aspects of quality of life were significantly improved after 28 days for each of the six criteria explored (P= 0.001). The duodenal ulcer healing rate was 86% after 4 weeks of treatment. Conclusions: Using complementary scales measuring different aspects of ulcer pain, sensory and affective components improved significantly from the second day of treatment with ranitidine 300 mg. A significant improvement in quality of life is observed after a 4-week treatment. QDSA and NHP appear to be useful evaluation tools of duodenal ulcer pain and quality of life." @default.
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- W2135187729 date "2007-03-31" @default.
- W2135187729 modified "2023-09-27" @default.
- W2135187729 title "Pain and quality of life in patients with acute duodenal ulcer treated with ranitidine" @default.
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- W2135187729 doi "https://doi.org/10.1111/j.1365-2036.1995.tb00402.x" @default.
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