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• W2135194733 abstract "Morpholin-2-one-5-carboxamide derivatives were prepared by using the one-pot Ugi multicomponent reaction and evaluated for blocking effects on T- and N-type Ca2+ channels. Among them, compound 5i produced the highest potency (IC50 = 0.45 ± 0.02 μM), while compounds 5d, 5f, 5k, 5n, 5o, and 6m produced relatively high potency as well as selectivity on T-type Ca2+ channels. These novel scaffolds showed potent and selective T-type Ca2+ channel blocking activities." @default.
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• W2135194733 date "2006-10-01" @default.
• W2135194733 modified "2023-10-18" @default.
• W2135194733 title "Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers" @default.
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• W2135194733 doi "https://doi.org/10.1016/j.bmcl.2006.05.031" @default.
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