FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135220132> ?p ?o ?g. }

• W2135220132 endingPage "5" @default.
• W2135220132 startingPage "1" @default.
• W2135220132 abstract "Objective . The aim of this study was to evaluate the effectiveness of thiamine pyrophosphate against cisplatin-induced ototoxicity in guinea pigs. Materials and Methods . Healthy guinea pigs (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>18</mml:mn></mml:math>) were randomly divided into three groups. Group 1 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>6</mml:mn></mml:math>) received an intraperitoneal injection of saline solution and cisplatin for 7 days, group 2 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>6</mml:mn></mml:math>) received an intraperitoneal injection of thiamine pyrophosphate and cisplatin for 7 days, and group 3 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>6</mml:mn></mml:math>) received only intraperitoneal injection of saline for 7 days. The animals in all groups were sacrificed under anesthesia, and their cochleas were harvested for morphological and biochemical observations. Results . In group 1, receiving only cisplatin, cochlear glutathione concentrations, superoxide dismutase, and glutathione peroxidase activities significantly decreased (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>) and malondialdehyde concentrations significantly increased (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>) compared to the control group. In group 2, receiving thiamine pyrophosphate and cisplatin, the concentrations of enzymes were near those of the control group. Microscopic examination showed that outer hair cells, spiral ganglion cells, and stria vascularis were preserved in group 2. Conclusion . Systemic administration of thiamine pyrophosphate yielded statistically significant protection to the cochlea of guinea pigs from cisplatin toxicity. Further experimental animal studies are essential to determine the appropriate indications of thiamine pyrophosphate before clinical use." @default.
• W2135220132 created "2016-06-24" @default.
• W2135220132 creator A5022040354 @default.
• W2135220132 creator A5029431695 @default.
• W2135220132 creator A5036185139 @default.
• W2135220132 creator A5039445496 @default.
• W2135220132 creator A5048280077 @default.
• W2135220132 date "2013-01-01" @default.
• W2135220132 modified "2023-09-27" @default.
• W2135220132 title "The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model" @default.
• W2135220132 cites W1987718442 @default.
• W2135220132 cites W2002071731 @default.
• W2135220132 cites W2024375371 @default.
• W2135220132 cites W2025940858 @default.
• W2135220132 cites W2028253379 @default.
• W2135220132 cites W2052832954 @default.
• W2135220132 cites W2056776118 @default.
• W2135220132 cites W2058129391 @default.
• W2135220132 cites W2072616434 @default.
• W2135220132 cites W2074540388 @default.
• W2135220132 cites W2082313150 @default.
• W2135220132 cites W2088329627 @default.
• W2135220132 cites W2093849396 @default.
• W2135220132 cites W2133944806 @default.
• W2135220132 cites W2148978886 @default.
• W2135220132 cites W2151956556 @default.
• W2135220132 cites W2159305277 @default.
• W2135220132 cites W758260955 @default.
• W2135220132 cites W969915667 @default.
• W2135220132 doi "https://doi.org/10.1155/2013/182694" @default.
• W2135220132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3791633" @default.
• W2135220132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24163613" @default.
• W2135220132 hasPublicationYear "2013" @default.
• W2135220132 type Work @default.
• W2135220132 sameAs 2135220132 @default.
• W2135220132 citedByCount "9" @default.
• W2135220132 countsByYear W21352201322014 @default.
• W2135220132 countsByYear W21352201322015 @default.
• W2135220132 countsByYear W21352201322017 @default.
• W2135220132 countsByYear W21352201322019 @default.
• W2135220132 countsByYear W21352201322020 @default.
• W2135220132 countsByYear W21352201322023 @default.
• W2135220132 crossrefType "journal-article" @default.
• W2135220132 hasAuthorship W2135220132A5022040354 @default.
• W2135220132 hasAuthorship W2135220132A5029431695 @default.
• W2135220132 hasAuthorship W2135220132A5036185139 @default.
• W2135220132 hasAuthorship W2135220132A5039445496 @default.
• W2135220132 hasAuthorship W2135220132A5048280077 @default.
• W2135220132 hasBestOaLocation W21352201321 @default.
• W2135220132 hasConcept C11413529 @default.
• W2135220132 hasConcept C185592680 @default.
• W2135220132 hasConcept C33923547 @default.
• W2135220132 hasConceptScore W2135220132C11413529 @default.
• W2135220132 hasConceptScore W2135220132C185592680 @default.
• W2135220132 hasConceptScore W2135220132C33923547 @default.
• W2135220132 hasLocation W21352201321 @default.
• W2135220132 hasLocation W21352201322 @default.
• W2135220132 hasLocation W21352201323 @default.
• W2135220132 hasLocation W21352201324 @default.
• W2135220132 hasOpenAccess W2135220132 @default.
• W2135220132 hasPrimaryLocation W21352201321 @default.
• W2135220132 hasRelatedWork W1531601525 @default.
• W2135220132 hasRelatedWork W1990781990 @default.
• W2135220132 hasRelatedWork W2314643286 @default.
• W2135220132 hasRelatedWork W2606768298 @default.
• W2135220132 hasRelatedWork W2606769243 @default.
• W2135220132 hasRelatedWork W2606837276 @default.
• W2135220132 hasRelatedWork W2748952813 @default.
• W2135220132 hasRelatedWork W2899084033 @default.
• W2135220132 hasRelatedWork W2948807893 @default.
• W2135220132 hasRelatedWork W2778153218 @default.
• W2135220132 hasVolume "2013" @default.
• W2135220132 isParatext "false" @default.
• W2135220132 isRetracted "false" @default.
• W2135220132 magId "2135220132" @default.
• W2135220132 workType "article" @default.