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• W2135236253 startingPage "1861" @default.
• W2135236253 abstract "The role of cyclin B-CDC2 as M phase-promoting factor (MPF) is well established, but the precise functions of cyclin A remain a crucial outstanding issue. Here we show that down-regulation of cyclin A induces a G2 phase arrest through a checkpoint-independent inactivation of cyclin B-CDC2 by inhibitory phosphorylation. The phenotype is rescued by expressing cyclin A resistant to the RNA interference. In contrast, down-regulation of cyclin B disrupts mitosis without inactivating cyclin A-CDK, indicating that cyclin A-CDK acts upstream of cyclin B-CDC2. Even when ectopically expressed, cyclin A cannot replace cyclin B in driving mitosis, indicating the specific role of cyclin B as a component of MPF. Deregulation of WEE1, but not the PLK1-CDC25 axis, can override the arrest caused by cyclin A knockdown, suggesting that cyclin A-CDK may tip the balance of the cyclin B-CDC2 bistable system by initiating the inactivation of WEE1. These observations show that cyclin A cannot form MPF independent of cyclin B and underscore a critical role of cyclin A as a trigger for MPF activation." @default.
• W2135236253 created "2016-06-24" @default.
• W2135236253 creator A5017217632 @default.
• W2135236253 creator A5025457462 @default.
• W2135236253 creator A5070555595 @default.
• W2135236253 date "2007-05-01" @default.
• W2135236253 modified "2023-10-02" @default.
• W2135236253 title "Specialized Roles of the Two Mitotic Cyclins in Somatic Cells: Cyclin A as an Activator of M Phase–promoting Factor" @default.
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• W2135236253 doi "https://doi.org/10.1091/mbc.e06-12-1092" @default.
• W2135236253 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1855023" @default.
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