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• W2135236956 abstract "BACKGROUND: Ibritumomab is an 90 Yttrium ( 90 Y) labelled radioimmunoconjugateregistered to treat follicular lymphoma relapsingor refractory after Rituximab therapy. Combining the specificityof anti CD20 monoclonal antibodies with the efficacy of radiotherapy,it is particularly effective in patients with advancedstages of disease with generalized lymphadenopathy. MATERIAL AND METHODS: Twenty-one patients with follicularlymphoma, after failing 2-5 lines of previous treatment,were subjected to radioimmunotherapy in three Polish LymphomaResearch Group (PLRG) centres. Ibritumomab infusionwas followed by 2 doses of Rituximab (250 mg/m 2 atday -7 and 0) to enhance its biodistribution. Radioimmunoconjugate was prepared in the Nuclear Medicine Departmentsof participating centres based on patient weight and full bloodcount results (14.8 MBq/kg, max 1200 MBq, reduced to 11.1MBq/kg in cases with blood platelet 100 000-150 000 or leukocytes1500-2000). 14.8 MBq/kg (0.4 mCi/kg) 100 thousand to 149 thousand/mm 3 platelets 11.1 MBq/kg (0.3 mCi/kg) RESULTS: The primary endpoint of the study was the assessmentof response rate and haematological toxicity. Objectiveresponses were observed in all patients, with 10 partial and 12complete regressions. Cytopenia, starting 3-4 weeks after radioimmunotherapy,reflected haematological toxicity - the onlyimportant side effect. Thrombocytopenia was more pronounced,with platelet counts of CONCLUSIONS: Ibritumomab radioimmunotherapy is an efficientmethod of palliation treatment of heavily pre-treated follicularlymphoma patients, failing numerous previous treatmentlines. Earlier application increases the number of complete responsesand prolongs progression free survival." @default.
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• W2135236956 date "2007-01-01" @default.
• W2135236956 modified "2023-09-26" @default.
• W2135236956 title "Radioimmunotherapy in follicular lymphomas, a retrospective analysis of the Polish Lymphoma Research Group's (PLRG) experience." @default.
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