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- W213524767 abstract "The different components of the biochemical background of radioresistance of yeast cells varying in resistance to radiation were examined, within the framework of a single species, and differing only in set of chromosomes. Pichia guilliermondii, in which, according to various data, radiosensitivity of cells with a diploid set of chromosomes is about twice as high as in cells with a haploid set was used. The levels of biogenous amines, hydroperoxides, and SOD activity were studied. The serotonin and histamine content of the more radioresistant haploid cells was found to be higher than the amine content of diploid cells. The more radioresistant haploid cells also demonstrated a decline of hydroperoxides of free fatty acids and high SOD activity. Thus, radioresistant yeast cells of this species are characterized by higher amounts of biologically active substances with radioprotective properties (biogenous amines and SOD) and lower levels of substances capable of exerting a radiosensitizing effect on the organism (hydroperoxides, the products of oxidation of higher unsaturated fatty acids). The aggregate of data warrants the conclusion that biologically active substances that have radioprotective and radiosensitizing properties are components of the endogenous biochemical background, both in the case of modified and different natural resistance of yeastmore » cells to ionizing radiation. (ERB)« less" @default.
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- W213524767 date "1978-01-01" @default.
- W213524767 modified "2023-09-24" @default.
- W213524767 title "Role of endogenous substances in creating a background of enhanced radioresistance. Report 10. The nature of differences in radioresistance of yeast cells (experiments on Pichia guilliermondii varying in ploidy). [uv and x rays]" @default.
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