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- W2135259853 abstract "Many patients taking customary doses of levothyroxine have slightly elevated serum thyroxine (T4), apparently normal serum triiodothyronine, suppressed serum thyrotropin (thyroid-stimulating hormone; TSH) concentrations, and no clinical symptoms of hyperthyroidism. Recent reports suggest that these patients may have adverse effects from subclinical hyperthyroidism, including abnormally short systolic time intervals, elevations in liver enzymes, and reductions in bone density. Controversy exists about which thyroid function tests should be used to monitor patients taking levothyroxine. A review of currently available data suggests that replacement doses of levothyroxine given to hypothyroid patients should be adjusted so that serum TSH measured by the new sensitive assays is within the normal range. Patients requiring suppressive doses of levothyroxine to shrink goitrous thyroid tissue or to prevent growth of abnormal tissue should be given the minimal dose needed to accomplish the desired clinical or biochemical response." @default.
- W2135259853 created "2016-06-24" @default.
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- W2135259853 date "1988-12-01" @default.
- W2135259853 modified "2023-10-04" @default.
- W2135259853 title "Subclinical Hyperthyroidism: Possible Danger of Overzealous Thyroxine Replacement Therapy" @default.
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- W2135259853 doi "https://doi.org/10.1016/s0025-6196(12)65409-3" @default.
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