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• W2135266519 endingPage "481" @default.
• W2135266519 startingPage "473" @default.
• W2135266519 abstract "Geometry, e.g., the shape of the environment, can be used by numerous animal species to orientate, but data concerning the mouse are lacking. We addressed the question of whether mice are capable of using geometry for navigating. To test whether aging could affect searching strategies, we compared adult (3- to 5-mo old) and aged (20- to 21-mo old) C57BL/6 male mice. We established a water maze task in which spatial information is provided by one landmark proximal to the target (featural information) and by the rectangular shape of the maze (geometric information). By means of probe trials in which we manipulated the presence of these two kinds of information, we show that adult mice can use both geometry and landmark to orientate. By contrast, aged mice do not use geometry and rely exclusively on the landmark to locate the platform. This study provides the first evidence that mice are capable of using geometric information for orientation and that this ability declines in aged animals." @default.
• W2135266519 created "2016-06-24" @default.
• W2135266519 creator A5004973809 @default.
• W2135266519 creator A5011330254 @default.
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• W2135266519 date "2006-07-01" @default.
• W2135266519 modified "2023-10-18" @default.
• W2135266519 title "Adult but not aged C57BL/6 male mice are capable of using geometry for orientation" @default.
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• W2135266519 doi "https://doi.org/10.1101/lm.259206" @default.
• W2135266519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1538925" @default.
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• W2135266519 hasPublicationYear "2006" @default.
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