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• W2135280679 abstract "ABSTRACT Aspergillus fumigatus , an important opportunistic pathogen which commonly affects neutropenic patients, produces conidia with a bluish-green color. We identified a gene, alb1 , which is required for conidial pigmentation. The alb1 gene encodes a putative polyketide synthase, and disruption of alb1 resulted in an albino conidial phenotype. Expression of alb1 is developmentally regulated, and the 7-kb transcript is detected only during the conidiation stage. The alb1 mutation was found to block 1,3,6,8-tetrahydroxynaphthalene production, indicating that alb1 is involved in dihydroxynaphthalene-melanin biosynthesis. Scanning electron microscopy studies showed that the alb1 disruptant exhibited a smooth conidial surface, whereas complementation of the alb1 deletion restored the echinulate wild-type surface. Disruption of alb1 resulted in a significant increase in C3 binding on conidial surfaces, and the conidia of the alb1 disruptant were ingested by human neutrophils at a higher rate than were those of the wild type. The alb1 -complemented strain producing bluish-green conidia exhibited inefficient C3 binding and neutrophil-mediated phagocytosis quantitatively similar to those of the wild type. Importantly, the alb1 disruptant had a statistically significant loss of virulence compared to the wild-type and alb1 -complemented strains in a murine model. These results suggest that disruption of alb1 causes pleiotropic effects on conidial morphology and fungal virulence." @default.
• W2135280679 created "2016-06-24" @default.
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• W2135280679 creator A5067802887 @default.
• W2135280679 date "1998-06-15" @default.
• W2135280679 modified "2023-10-12" @default.
• W2135280679 title "The Developmentally Regulated <i>alb1</i> Gene of <i>Aspergillus fumigatus</i> : Its Role in Modulation of Conidial Morphology and Virulence" @default.
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• W2135280679 doi "https://doi.org/10.1128/jb.180.12.3031-3038.1998" @default.
• W2135280679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/107801" @default.
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